RT Journal Article T1 Challenges in Diabetic Macular Edema Management: An Expert Consensus Report. A1 Udaondo, Patricia A1 Adan, Alfredo A1 Arias-Barquet, Luis A1 Ascaso, Francisco J A1 Cabrera-López, Francisco A1 Castro-Navarro, Verónica A1 Donate-López, Juan A1 García-Layana, Alfredo A1 Lavid, Francisco Javier A1 Rodríguez-Maqueda, Mariano A1 Ruiz-Moreno, José María K1 biomarkers K1 consensus K1 diabetes K1 diabetic macular edema K1 inflammation K1 optical coherence tomography AB This paper aimed to present daily-practice recommendations for the management of diabetic macular edema (DME) patients based on available scientific evidence and the clinical experience of the consensus panel. A group of Spanish retina experts agreed to discuss different aspects related with the clinical management of DME patients. Panel was mainly focused on therapeutic objectives in DME management; definition terms; and role of biomarkers as prognostic and predictive factors to intravitreal treatment response. The panel recommends to start DME treatment as soon as possible in those eyes with a visual acuity less than 20/25 (always according to the retina unit capacity). Naïve patient was defined, in a strict manner, as a patient who, up to that moment, had never received any treatment. A refractory DME patient may be defined as the one who did not achieve a complete resolution of the disease, regardless of the treatment administered. Different optical coherence tomography biomarkers, such as disorganization of the retinal inner layers, hyperreflective dots, and cysts, have been identified as prognostic factors. This document has sought to lay down a set of recommendations and to identify key issues that may be useful for the daily management of DME patients. SN 1177-5467 YR 2021 FD 2021-07-27 LK http://hdl.handle.net/10668/18293 UL http://hdl.handle.net/10668/18293 LA en DS RISalud RD Apr 10, 2025