RT Journal Article
T1 Macronutrient composition of the diet and prospective weight change in participants of the EPIC-PANACEA study.
A1 Vergnaud, Anne-Claire
A1 Norat, Teresa
A1 Mouw, Traci
A1 Romaguera, Dora
A1 May, Anne M
A1 Bueno-de-Mesquita, H Bas
A1 van der A, Daphne
A1 Agudo, Antonio
A1 Wareham, Nicholas
A1 Khaw, Kay-Tee
A1 Romieu, Isabelle
A1 Freisling, Heinz
A1 Slimani, Nadia
A1 Perquier, Florence
A1 Boutron-Ruault, Marie-Christine
A1 Clavel-Chapelon, Françoise
A1 Palli, Domenico
A1 Berrino, Franco
A1 Mattiello, Amalia
A1 Tumino, Rosario
A1 Ricceri, Fulvio
A1 Rodríguez, Laudina
A1 Molina-Montes, Esther
A1 Amiano, Pilar
A1 Barricarte, Aurelio
A1 Chirlaque, Maria-Dolores
A1 Crowe, Francesca L
A1 Orfanos, Philippos
A1 Naska, Androniki
A1 Trichopoulou, Antonia
A1 Teucher, Birgit
A1 Kaaks, Rudolf
A1 Boeing, Heiner
A1 Buijsse, Brian
A1 Johansson, Ingeged
A1 Hallmans, Göran
A1 Drake, Isabel
A1 Sonestedt, Emily
A1 Jakobsen, Marianne Uhre
A1 Overvad, Kim
A1 Tjønneland, Anne
A1 Halkjær, Jytte
A1 Skeie, Guri
A1 Braaten, Tonje
A1 Lund, Eiliv
A1 Riboli, Elio
A1 Peeters, Petra H M
K1 Adulto
K1 Anciano
K1 Índice de Masa Corporal
K1 Dieta
K1 Carbohidratos en la Dieta
K1 Proteínas en la Dieta
K1 Ingestión de Energía
K1 Europa
K1 Humanos
K1 Modelos Lineales
K1 Mediana Edad
K1 Obesidad
K1 Sobrepeso
K1 Distribución de Poisson
K1 Estudios Prospectivos
K1 Cuestionarios
K1 Factores de riesgo
K1 Aumento de Peso
AB BACKGROUNDThe effect of the macronutrient composition of the usual diet on long term weight maintenance remains controversial.METHODS373,803 subjects aged 25-70 years were recruited in 10 European countries (1992-2000) in the PANACEA project of the EPIC cohort. Diet was assessed at baseline using country-specific validated questionnaires and weight and height were measured at baseline and self-reported at follow-up in most centers. The association between weight change after 5 years of follow-up and the iso-energetic replacement of 5% of energy from one macronutrient by 5% of energy from another macronutrient was assessed using multivariate linear mixed-models. The risk of becoming overweight or obese after 5 years was investigated using multivariate Poisson regressions stratified according to initial Body Mass Index.RESULTSA higher proportion of energy from fat at the expense of carbohydrates was not significantly associated with weight change after 5 years. However, a higher proportion of energy from protein at the expense of fat was positively associated with weight gain. A higher proportion of energy from protein at the expense of carbohydrates was also positively associated with weight gain, especially when carbohydrates were rich in fibre. The association between percentage of energy from protein and weight change was slightly stronger in overweight participants, former smokers, participants ≥60 years old, participants underreporting their energy intake and participants with a prudent dietary pattern. Compared to diets with no more than 14% of energy from protein, diets with more than 22% of energy from protein were associated with a 23-24% higher risk of becoming overweight or obese in normal weight and overweight subjects at baseline.CONCLUSIONOur results show that participants consuming an amount of protein above the protein intake recommended by the American Diabetes Association may experience a higher risk of becoming overweight or obese during adult life.
PB Public Library of Science
YR 2013
FD 2013-03-05
LK http://hdl.handle.net/10668/1492
UL http://hdl.handle.net/10668/1492
LA en
NO Vergnaud AC, Norat T, Mouw T, Romaguera D, May AM, Bueno-de-Mesquita HB, et al. Macronutrient composition of the diet and prospective weight change in participants of the EPIC-PANACEA study. PLoS ONE 2013; 8(3):e57300
NO Journal Article; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 12, 2025