RT Journal Article
T1 Effects of SHBG rs1799941 Polymorphism on Free Testosterone Levels and Hypogonadism Risk in Young Non-Diabetic Obese Males.
A1 Castellano-Castillo, Daniel
A1 Royo, José Luis
A1 Martínez-Escribano, Ana
A1 Sánchez-Alcoholado, Lidia
A1 Molina-Vega, María
A1 Queipo-Ortuño, María Isabel
A1 Ruiz-Galdon, Maximiliano
A1 J Álvarez-Millán, Juan
A1 Cabezas-Sanchez, Pablo
A1 Reyes-Engel, Armando
A1 Tinahones, Francisco J
A1 Cardona, Fernando
A1 Fernandez-Garcia, José C
K1 SHBG
K1 free testosterone
K1 hypogonadism
K1 obesity
K1 polymorphism
K1 rs1799941
AB Obesity has been associated with increased risk of presenting hypogonadism. Free testosterone (FT) is the fraction of testosterone that carries out the biological function of testosterone, and is determined from total testosterone (TT) and sex-hormone binding globulin (SHBG) levels. We aimed to study the SHBG polymorphism rs1799941 in a cohort of young non-diabetic obese males to unravel the possible implication of this polymorphism in obesity-related hypogonadism. 212 young ( 3.5 ng/mL and FT ≥ 70 pg/mL; EuG), normal FT hypogonadism (n = 40, TT  The rs1799941 frequencies were different among the groups. Higher proportion of the allele (A) was found in HG, compared to EuG and normal FT HG. Among the genotypes, the rare homozygous (AA) were found in the normal FT HG group and higher levels of serum SHBG and lower of FT were observed. The presence of the allele A was related (according to lineal regression models) to an increased of SHBG levels ((GA) β = 3.28; (AA) β = 12.45) and a decreased of FT levels ((GA) β = -9.19; (AA) β = -18.52). The presence of the allele (A) increased the risk of presenting HG compared to normal FT HG (OR = 2.54). The rs1799941 of the SHBG gene can partially determine the presence of obesity-related hypogonadism in young non-diabetic males and whether these subjects have normal FT HG.
SN 2077-0383
YR 2019
FD 2019-07-31
LK http://hdl.handle.net/10668/14351
UL http://hdl.handle.net/10668/14351
LA en
DS RISalud
RD Apr 8, 2025