TY  - JOUR
AU  - Temps, Carolin
AU  - Lietha, Daniel
AU  - Webb, Emily R
AU  - Li, Xue-Feng
AU  - Dawson, John C
AU  - Muir, Morwenna
AU  - Macleod, Kenneth G
AU  - Valero, Teresa
AU  - Munro, Alison F
AU  - Contreras-Montoya, Rafael
AU  - Luque-Ortega, Juan R
AU  - Fraser, Craig
AU  - Beetham, Henry
AU  - Schoenherr, Christina
AU  - Lopalco, Maria
AU  - Arends, Mark J
AU  - Frame, Margaret C
AU  - Qian, Bin-Zhi
AU  - Brunton, Valerie G
AU  - Carragher, Neil O
AU  - Unciti-Broceta, Asier
PY  - 2021
DO  - 10.1158/0008-5472.CAN-21-0613
UR  - https://hdl.handle.net/10668/24919
T2  - Cancer research
AB  - Despite the approval of several multikinase inhibitors that target SRC and the overwhelming evidence of the role of SRC in the progression and resistance mechanisms of many solid malignancies, inhibition of its kinase activity has thus far failed to...
LA  - en
KW  - Animals
KW  - Apoptosis
KW  - Bone Neoplasms
KW  - Breast Neoplasms
KW  - Cell Proliferation
KW  - Female
KW  - Focal Adhesion Kinase 1
KW  - Humans
KW  - Mice
KW  - Mice, Inbred BALB C
KW  - Mice, Nude
KW  - Piperidines
KW  - Protein Conformation
KW  - Protein Kinase Inhibitors
KW  - Proto-Oncogene Proteins c-abl
KW  - Pyrazoles
KW  - Pyrimidines
KW  - Small Molecule Libraries
KW  - Tumor Cells, Cultured
KW  - Xenograft Model Antitumor Assays
KW  - src-Family Kinases
TI  - A Conformation Selective Mode of Inhibiting SRC Improves Drug Efficacy and Tolerability.
TY  - research article
VL  - 81
ER  -