%0 Journal Article
%A Toribio, María José
%A Priego-Capote, Feliciano
%A Pérez-Gómez, Beatriz
%A Fernández de Larrea-Baz, Nerea
%A Ruiz-Moreno, Emma
%A Castelló, Adela
%A Lucas, Pilar
%A Sierra, María Ángeles
%A Pino, Marina Nieves
%A Martínez-Cortés, Mercedes
%A Luque de Castro, María Dolores
%A Lope, Virginia
%A Pollán, Marina
%T Factors Associated with Serum Vitamin D Metabolites and Vitamin D Metabolite Ratios in Premenopausal Women.
%D 2021
%U https://hdl.handle.net/10668/25638
%X The most representative indicator of vitamin D status in clinical practice is 25(OH)D3, but new biomarkers could improve the assessment of vitamin D status and metabolism. The objective of this study is to investigate the association of serum vitamin D metabolites and vitamin D metabolite ratios (VMRs) with potentially influential factors in premenopausal women. This is a cross-sectional study based on 1422 women, aged 39-50, recruited from a Madrid Medical Diagnostic Center. Participants answered an epidemiological and a food frequency questionnaire. Serum vitamin D metabolites were determined using an SPE-LC-MS/MS platform. The association between participant's characteristics, vitamin D metabolites, and VMRs was quantified by multiple linear regression models. Mean 25(OH)D3 concentration was 49.2 + 18.9 nmol/L, with greater deficits among obese, nulliparous, dark-skinned women, and with less sun exposure. A lower R2 ratio (1,25(OH)2D3/25(OH)D3) and a higher R4 (24,25(OH)2D3/1,25(OH)2D3) were observed in nulliparous women, with high sun exposure, and those with low caloric intake or high consumption of calcium, vitamin D supplements, or alcohol. Nulliparous women had lower R1 (25(OH)D3/Vit D3) and R3 (24,25(OH)2D3/25(OH)D3), and older women showed lower R3 and R4. Vitamin D status modified the association of the VMRs with seasons. VMRs can be complementary indicators of vitamin D status and its endogenous metabolism, and reveal the influence of certain individual characteristics on the expression of hydroxylase enzymes.
%K 1,25(OH)2D3
%K 24,25(OH)2D3
%K 25(OH)D3
%K Vit D3
%K vitamin D metabolite ratios
%~