RT Journal Article
T1 Listeriosis in pregnancy: An umbrella review of maternal exposure, treatment and neonatal complications.
A1 Khsim, Ijlas El Founti
A1 Mohanaraj-Anton, Ahalini
A1 Horte, Ivar Benjamin
A1 Lamont, Ronald Francis
A1 Khan, Khalid Saeed
A1 Jørgensen, Jan Stener
A1 Amezcua-Prieto, Carmen
K1 diagnosis
K1 listeriosis
K1 neonate
K1 newborn
K1 pregnancy
K1 prevention
K1 treatment
AB Listeria monocytogenes is a commonly found organism in processed and prepared food and the disease of listeriosis is associated with a high morbidity and mortality. Compared with the general population, the risk of being diagnosed with listeriosis increases during pregnancy. Listeriosis can lead to miscarriage, spontaneous preterm labour and preterm birth, stillbirth and congenital neonatal infections. We conducted a universal review of listeriosis in pregnancy and in the newborn. The EMBASE, PubMed, Cinahl and Web of Science databases were searched for systematic reviews indexed before 1 December 2020. Any systematic reviews evaluating the prevalence, treatment, diagnosis and effects of listeriosis during pregnancy and up to 4 weeks postnatally were included. Eligibility assessment, data extraction and quality assessment by the Methodological Quality Assessment of Systematic Reviews (AMSTAR-2) were performed in duplicate. We identified 397 citations of which nine systematic reviews comprising 330 studies and 487 patients' reviews were included. Most systematic reviews (seven of nine) were of moderate to high quality. Prevention in pregnant women was based on adherence to strict dietary recommendations, such as reheating leftovers until steamed and avoiding unpasteurised dairy products. Listeriosis infections were likely to occur in the third trimester (66%) rather than in the first trimester (3%) of pregnancy. Symptoms are mostly fever and other flu-like symptoms, such as fatigue. Diagnosis was primarily made by culture of the pathogen. Intravenous amoxicillin or ampicillin were first-line treatment. Listeriosis, a rare but serious infectious disease in pregnancy, can cause devastating consequences for the fetus and newborn. Appropriate preventative treatment should be initiated during early pregnancy to avoid complications. Listeria is commonly found in processed and prepared food. Prevention is the best way to avoid listeriosis during pregnancy.
PB Wiley-Blackwell Publishing Ltd.
YR 2021
FD 2021-11-22
LK http://hdl.handle.net/10668/19880
UL http://hdl.handle.net/10668/19880
LA en
NO Khsim IEF, Mohanaraj-Anton A, Horte IB, Lamont RF, Khan KS, Jørgensen JS, et al. Listeriosis in pregnancy: An umbrella review of maternal exposure, treatment and neonatal complications. BJOG. 2022 Aug;129(9):1427-1433.
DS RISalud
RD Apr 11, 2025