RT Journal Article
T1 Sleep-Disordered Breathing Is Independently Associated With Increased Aggressiveness of Cutaneous Melanoma: A Multicenter Observational Study in 443 Patients.
A1 Martinez-Garcia, Miguel Angel
A1 Campos-Rodriguez, Francisco
A1 Nagore, Eduardo
A1 Martorell, Antonio
A1 Rodriguez-Peralto, Jose Luis
A1 Riveiro-Falkenbach, Erica
A1 Hernandez, Luis
A1 Bañuls, Jose
A1 Arias, Eva
A1 Ortiz, Pablo
A1 Cabriada, Valentin
A1 Gardeazabal, Jose
A1 Montserrat, Josep Maria
A1 Carrera, Cristina
A1 Corral, Jaime
A1 Masa, Juan Fernando
A1 de Terreros, Javier Gomez
A1 Abad, Jorge
A1 Boada, Adam
A1 Mediano, Olga
A1 de Eusebio, Esther
A1 Chiner, Eusebi
A1 Landete, Pedro
A1 Mayos, Mercedes
A1 Fortuño, Ana
A1 Barbé, Ferrán
A1 Sánchez de la Torre, Manuel
A1 Sanchez de la Torre, Alicia
A1 Cano, Irene
A1 Gonzalez, Cristina
A1 Pérez-Gil, Amalia
A1 Gómez-García, Teresa
A1 Cullen, Daniela
A1 Somoza, Maria
A1 Formigón, Manuel
A1 Aizpuru, Felipe
A1 Navarro, Cristina
A1 Selma-Ferrer, Maria Jose
A1 Garcia-Ortega, Alberto
A1 de Unamuno, Blanca
A1 Almendros, Isaac
A1 Farré, Ramón
A1 Gozal, David
A1 Spanish Sleep Network, 
K1 Breslow index
K1 melanoma aggressiveness
K1 sleep apnea
K1 sleep-disordered breathing
AB Sleep-disordered breathing (SDB) has been associated with a greater incidence and mortality of cancer, although such findings are inconsistent. However, no large studies are currently available to investigate this association in patients with a specific type of cancer. This study seeks to assess potential relationships between SDB severity and aggressiveness markers of cutaneous melanoma. Four hundred and forty-three patients with a diagnosis of melanoma underwent a sleep study within 6 months of diagnosis. General demographics were collected, along with melanoma characteristics and polygraphic parameters consisting of the apnea-hypopnea index (AHI) and indices of both continuous and intermittent night-time oxyhemoglobin desaturation (DI4%). An exploration of independent relationships between SDB and various objective melanoma aggressiveness markers (Breslow index, presence of ulceration, presence of regression, mitotic index, stage of severity, damage to the sentinel lymph, and spreading of the melanoma) was performed. Patients in the upper tertiles of AHI or DI4% were 1.94 (95% CI, 1.14-3.32; P = .022) and 1.93 (95% CI, 1.14-3.26; P = .013) times more likely, respectively, to present with aggressive melanoma (Breslow index > 1 mm) than those in the lowest tertiles of these sleep attributes after adjustment for age, sex, tumor location, and BMI. This association was particularly prominent among patients  1 mm) than those in the lowest tertiles of these sleep attributes after adjustment for age, sex, tumor location, and BMI. This association was particularly prominent among patients  2 mm. The presence of the additional markers of aggressiveness was also associated with higher AHI and DI4% values. The severity of SDB was independently associated with greater aggressiveness of cutaneous melanoma, particularly among younger patients.
YR 2018
FD 2018-07-27
LK http://hdl.handle.net/10668/12774
UL http://hdl.handle.net/10668/12774
LA en
DS RISalud
RD Apr 6, 2025