RT Journal Article
T1 Overlapping of Pulmonary Fibrosis of Postacute COVID-19 Syndrome and Tuberculosis in the Helminth Coinfection Setting in Sub-Saharan Africa.
A1 Fonte, Luis
A1 Acosta, Armando
A1 Sarmiento, María E
A1 Norazmi, Mohd Nor
A1 Ginori, María
A1 de Armas, Yaxsier
A1 Calderón, Enrique J
K1 helminth coinfection
K1 postacute COVID-19 syndrome
K1 pulmonary fibrosis
K1 sub-Saharan Africa
K1 tuberculosis
AB There is an increasing attention to the emerging health problem represented by the clinical and functional long-term consequences of SARS-CoV-2 infection, referred to as postacute COVID-19 syndrome. Clinical, radiographic, and autopsy findings have shown that a high rate of fibrosis and restriction of lung function are present in patients who have recovered from COVID-19. Patients with active TB, or those who have recovered from it, have fibrotic scarred lungs and, consequently, some degree of impaired respiratory function. Helminth infections trigger predominantly type 2 immune responses and the release of regulatory and fibrogenic cytokines, such as TGF-β. Here, we analyze the possible consequences of the overlapping of pulmonary fibrosis secondary to COVID-19 and tuberculosis in the setting of sub-Saharan Africa, the region of the world with the highest prevalence of helminth infection.
YR 2022
FD 2022-07-30
LK http://hdl.handle.net/10668/21595
UL http://hdl.handle.net/10668/21595
LA en
DS RISalud
RD Apr 6, 2025