RT Journal Article
T1 Gut microbiota, innate immune pathways, and inflammatory control mechanisms in patients with major depressive disorder
A1 Caso, Javier R.
A1 MacDowell, Karina S.
A1 Gonzalez-Pinto, Ana
A1 Garcia, Sainza
A1 De Diego-Adelino, Javier
A1 Carceller-Sindreu, Mar
A1 Sarramea, Fernando
A1 Caballero-Villarraso, Javier
A1 Gracia-Garcia, Patricia
A1 De la Camara, Concepcion
A1 Aguera, Luis
A1 Gomez-Lus, Maria L.
A1 Alba, Claudio
A1 Rodriguez, Juan M.
A1 Leza, Juan C.
K1 Butyrate-producing bacterium
K1 Necrosis-factor-alpha
K1 Sp-nov.
K1 Psychometric properties
K1 Fecal microbiota
K1 Gene-expression
K1 Spanish version
K1 Metaanalysis
K1 Stress
K1 Impact
AB Although alterations in the gut microbiota have been linked to the pathophysiology of major depressive disorder (MDD), including through effects on the immune response, our understanding is deficient about the straight connection patterns among microbiota and MDD in patients. Male and female MDD patients were recruited: 46 patients with a current active MDD (a-MDD) and 22 in remission or with only mild symptoms (r-MDD). Forty-five healthy controls (HC) were also recruited. Psychopathological states were assessed, and fecal and blood samples were collected. Results indicated that the inducible nitric oxide synthase expression was higher in MDD patients compared with HC and the oxidative stress levels were greater in the a-MDD group. Furthermore, the lipopolysaccharide (an indirect marker of bacterial translocation) was higher in a-MDD patients compared with the other groups. Fecal samples did not cluster according to the presence or the absence of MDD. There were bacterial genera whose relative abundance was altered in MDD: Bilophila (2-fold) and Alistipes (1.5-fold) were higher, while Anaerostipes (1.5-fold) and Dialister (15-fold) were lower in MDD patients compared with HC. Patients with a-MDD presented higher relative abundance of Alistipes and Anaerostipes (1.5-fold) and a complete depletion of Dialister compared with HC. Patients with r-MDD presented higher abundance of Bilophila (2.5-fold) compared with HC. Thus, the abundance of bacterial genera and some immune pathways, both with potential implications in the pathophysiology of depression, appear to be altered in MDD, with the most noticeable changes occurring in patients with the worse clinical condition, the a-MDD group.
PB Springernature
SN 2158-3188
YR 2021
FD 2021-12-21
LK https://hdl.handle.net/10668/25509
UL https://hdl.handle.net/10668/25509
LA en
DS RISalud
RD Apr 11, 2025