TY - JOUR AU - Sarmiento Soto, Manuel AU - Larkin, James R AU - Martin, Chris AU - Khrapitchev, Alexandre A AU - Maczka, Melissa AU - Economopoulos, Vasiliki AU - Scott, Helen AU - Escartin, Carole AU - Bonvento, Gilles AU - Serres, Sébastien AU - Sibson, Nicola R PY - 2020 DO - 10.1158/0008-5472.CAN-20-2251 UR - http://hdl.handle.net/10668/16481 T2 - Cancer research AB - Astrocytes are thought to play a pivotal role in coupling neural activity and cerebral blood flow. However, it has been shown that astrocytes undergo morphologic changes in response to brain metastasis, switching to a reactive phenotype, which has the... LA - en KW - Animals KW - Astrocytes KW - Brain Neoplasms KW - Cell Line, Tumor KW - Cerebrovascular Circulation KW - Ciliary Neurotrophic Factor KW - Female KW - Humans KW - Laser Speckle Contrast Imaging KW - Magnetic Resonance Spectroscopy KW - Multimodal Imaging KW - Neoplasms, Experimental KW - Pyridines KW - Rats KW - Rats, Inbred Strains KW - STAT3 Transcription Factor KW - Tyrphostins TI - STAT3-Mediated Astrocyte Reactivity Associated with Brain Metastasis Contributes to Neurovascular Dysfunction. TY - research article VL - 80 ER -