RT Journal Article
T1 Identifying comorbidities and lifestyle factors contributing to the cognitive profile of early Parkinson's disease
A1 Martinez-Horta, Saul
A1 Bejr-Kasem, Helena
A1 Horta-Barba, Andrea
A1 Pascual-Sedano, Berta
A1 Santos-Garcia, Diego
A1 De Deus-Fonticoba, Teresa
A1 Jesus, Silvia
A1 Aguilar, Miquel
A1 Planellas, Lluis
A1 Garcia-Caldentey, Juan
A1 Caballol, Nuria
A1 Vives-Pastor, Barbara
A1 Hernandez-Vara, Jorge
A1 Cabo-Lopez, Iria
A1 Lopez-Manzanares, Lydia
A1 Gonzalez-Aramburu, Isabel
A1 Asuncion Avila-Rivera, Maria
A1 Jose Catalan, Maria
A1 Manuel Lopez-Diaz, Luis
A1 Puente, Victor
A1 Manuel Garcia-Moreno, Jose
A1 Borrue, Carmen
A1 Solano-Vila, Berta
A1 Alvarez-Sauco, Maria
A1 Vela, Lydia
A1 Escalante, Sonia
A1 Cubo, Esther
A1 Carrillo-Padilla, Francisco
A1 Carlos Martinez-Castrillo, Juan
A1 Sanchez-Alonso, Pilar
A1 Gema Alonso-Losada, Maria
A1 Lopez-Ariztegui, Nuria
A1 Gaston, Itziar
A1 Blazquez-Estrada, Marta
A1 Seijo-Martinez, Manual
A1 Ruiz-Martinez, Javier
A1 Valero-Merino, Caridad
A1 Kurtis, Monica
A1 De Fabregues-Boixar, Oriol
A1 Gonzalez-Ardura, Jessica
A1 Prieto-Jurczynska, Cristina
A1 Martinez-Martin, Pablo
A1 Mir, Pablo
A1 Kulisevsky, Jaime
A1 COPPADIS Study, 
K1 Parkinson's disease
K1 PD-MCI
K1 Cognition
K1 Lifestyle
K1 Coppadis
K1 Plasma homocysteine levels
K1 Dementia
K1 Impairment
K1 Decline
K1 Risk
K1 Association
K1 Multicenter
K1 Prevalence
K1 Cytokines
K1 Beta
AB Background Identifying modifiable risk factors for cognitive impairment in the early stages of Parkinson's disease (PD) and estimating their impact on cognitive status may help prevent dementia (PDD) and the design of cognitive trials. Methods Using a standard approach for the assessment of global cognition in PD and controlling for the effects of age, education and disease duration, we explored the associations between cognitive status, comorbidities, metabolic variables and lifestyle variables in 533 PD participants from the COPPADIS study. Results Among the overall sample, 21% of participants were classified as PD-MCI (n = 114) and 4% as PDD (n = 26). The prevalence of hypertension, diabetes and dyslipidemia was significantly higher in cognitively impaired patients while no between-group differences were found for smoking, alcohol intake or use of supplementary vitamins. Better cognitive scores were significantly associated with regular physical exercise (p
PB Bmc
YR 2021
FD 2021-12-08
LK https://hdl.handle.net/10668/27946
UL https://hdl.handle.net/10668/27946
LA en
DS RISalud
RD Apr 17, 2025