RT Journal Article
T1 Mutational Characterization of Cutaneous Melanoma Supports Divergent Pathways Model for Melanoma Development.
A1 Millán-Esteban, David
A1 Peña-Chilet, María
A1 García-Casado, Zaida
A1 Manrique-Silva, Esperanza
A1 Requena, Celia
A1 Bañuls, José
A1 López-Guerrero, Jose Antonio
A1 Rodríguez-Hernández, Aranzazu
A1 Traves, Víctor
A1 Dopazo, Joaquín
A1 Virós, Amaya
A1 Kumar, Rajiv
A1 Nagore, Eduardo
K1 etiopathogeny
K1 melanoma
K1 mutations
AB According to the divergent pathway model, cutaneous melanoma comprises a nevogenic group with a propensity to melanocyte proliferation and another one associated with cumulative solar damage (CSD). While characterized clinically and epidemiologically, the differences in the molecular profiles between the groups have remained primarily uninvestigated. This study has used a custom gene panel and bioinformatics tools to investigate the potential molecular differences in a thoroughly characterized cohort of 119 melanoma patients belonging to nevogenic and CSD groups. We found that the nevogenic melanomas had a restricted set of mutations, with the prominently mutated gene being BRAF. The CSD melanomas, in contrast, showed mutations in a diverse group of genes that included NF1, ROS1, GNA11, and RAC1. We thus provide evidence that nevogenic and CSD melanomas constitute different biological entities and highlight the need to explore new targeted therapies.
SN 2072-6694
YR 2021
FD 2021-10-18
LK https://hdl.handle.net/10668/24618
UL https://hdl.handle.net/10668/24618
LA en
DS RISalud
RD Apr 8, 2025