RT Journal Article
T1 The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe: A Comprehensive Review.
A1 Louro, Henriqueta
A1 Gomes, Bruno Costa
A1 Saber, Anne Thoustrup
A1 Iamiceli, Anna Laura
A1 Göen, Thomas
A1 Jones, Kate
A1 Katsonouri, Andromachi
A1 Neophytou, Christiana M
A1 Vogel, Ulla
A1 Ventura, Célia
A1 Oberemm, Axel
A1 Duca, Radu Corneliu
A1 Fernandez, Mariana F
A1 Olea, Nicolas
A1 Santonen, Tiina
A1 Viegas, Susana
A1 Silva, Maria João
K1 effect biomarker
K1 exposure biomarker
K1 human biomonitoring
K1 occupational exposure
K1 polycyclic aromatic hydrocarbons
AB Polycyclic aromatic hydrocarbons (PAHs) are among the chemicals with proven impact on workers' health. The use of human biomonitoring (HBM) to assess occupational exposure to PAHs has become more common in recent years, but the data generated need an overall view to make them more usable by regulators and policymakers. This comprehensive review, developed under the Human Biomonitoring for Europe (HBM4EU) Initiative, was based on the literature available from 2008-2022, aiming to present and discuss the information on occupational exposure to PAHs, in order to identify the strengths and limitations of exposure and effect biomarkers and the knowledge needs for regulation in the workplace. The most frequently used exposure biomarker is urinary 1-hydroxypyrene (1-OH-PYR), a metabolite of pyrene. As effect biomarkers, those based on the measurement of oxidative stress (urinary 8-oxo-dG adducts) and genotoxicity (blood DNA strand-breaks) are the most common. Overall, a need to advance new harmonized approaches both in data and sample collection and in the use of appropriate biomarkers in occupational studies to obtain reliable and comparable data on PAH exposure in different industrial sectors, was noted. Moreover, the use of effect biomarkers can assist to identify work environments or activities of high risk, thus enabling preventive risk mitigation and management measures.
PB MDPI AG
YR 2022
FD 2022-08-13
LK http://hdl.handle.net/10668/21589
UL http://hdl.handle.net/10668/21589
LA en
NO Louro H, Gomes BC, Saber AT, Iamiceli AL, Göen T, Jones K, et al. The Use of Human Biomonitoring to Assess Occupational Exposure to PAHs in Europe: A Comprehensive Review. Toxics. 2022 Aug 17;10(8):480.
DS RISalud
RD Apr 10, 2025