RT Journal Article
T1 A nomogram for predicting complications in patients with solid tumours and seemingly stable febrile neutropenia.
A1 Fonseca, Paula Jiménez
A1 Carmona-Bayonas, Alberto
A1 García, Ignacio Matos
A1 Marcos, Rosana
A1 Castañón, Eduardo
A1 Antonio, Maite
A1 Font, Carme
A1 Biosca, Mercè
A1 Blasco, Ana
A1 Lozano, Rebeca
A1 Ramchandani, Avinash
A1 Beato, Carmen
A1 de Castro, Eva Martínez
A1 Espinosa, Javier
A1 Martínez-García, Jerónimo
A1 Ghanem, Ismael
A1 Cubero, Jorge Hernando
A1 Manrique, Isabel Aragón
A1 Navalón, Francisco García
A1 Sevillano, Elena
A1 Manzano, Aránzazu
A1 Virizuela, Juan
A1 Garrido, Marcelo
A1 Mondéjar, Rebeca
A1 Arcusa, María Ángeles
A1 Bonilla, Yaiza
A1 Pérez, Quionia
A1 Gallardo, Elena
A1 Del Carmen Soriano, Maria
A1 Cardona, Mercè
A1 Lasheras, Fernando Sánchez
A1 Cruz, Juan Jesús
A1 Ayala, Francisco
AB We sought to develop and externally validate a nomogram and web-based calculator to individually predict the development of serious complications in seemingly stable adult patients with solid tumours and episodes of febrile neutropenia (FN). The data from the FINITE study (n=1133) and University of Salamanca Hospital (USH) FN registry (n=296) were used to develop and validate this tool. The main eligibility criterion was the presence of apparent clinical stability, defined as events without acute organ dysfunction, abnormal vital signs, or major infections. Discriminatory ability was measured as the concordance index and stratification into risk groups. The rate of infection-related complications in the FINITE and USH series was 13.4% and 18.6%, respectively. The nomogram used the following covariates: Eastern Cooperative Group (ECOG) Performance Status ⩾2, chronic obstructive pulmonary disease, chronic cardiovascular disease, mucositis of grade ⩾2 (National Cancer Institute Common Toxicity Criteria), monocytes 0.1). The concordance index was 0.855 and 0.831 in each series. Risk group stratification revealed a significant distinction in the proportion of complications. With a ⩾116-point cutoff, the nomogram yielded the following prognostic indices in the USH registry validation series: 66% sensitivity, 83% specificity, 3.88 positive likelihood ratio, 48% positive predictive value, and 91% negative predictive value. We have developed and externally validated a nomogram and web calculator to predict serious complications that can potentially impact decision-making in patients with seemingly stable FN.
YR 2016
FD 2016-05-17
LK http://hdl.handle.net/10668/10093
UL http://hdl.handle.net/10668/10093
LA en
DS RISalud
RD Apr 13, 2025