RT Journal Article
T1 Dietary folate intake and metabolic syndrome in participants of PREDIMED‑Plus study: a cross‑sectional study.
A1 Navarrete-Muñoz, Eva-Maria
A1 Vioque, Jesus
A1 Toledo, Estefania
A1 Oncina-Canovas, Alejando
A1 Martinez-Gonzalez, Miguel Angel
A1 Salas-Salvado, Jordi
A1 Corella, Dolores
A1 Fito, Montserrat
A1 Romaguera, Dora
A1 Alonso-Gomez, Angel M
A1 Wärnberg, Julia
A1 Martínez, J Alfredo
A1 Serra-Majem, Luís
A1 Estruch, Ramon
A1 Tinahones, Francisco J
A1 Lapetra, Jose
A1 Pinto, Xavier
A1 Tur, Josep A
A1 Lopez-Miranda, Jose
A1 Bueno-Cavanillas, Aurora
A1 Matia-Martin, Pilar
A1 Daimiel, Lidia
A1 Martin-Sanchez, Vicente
A1 Vidal, Josep
A1 de-Cos-Blanco, Ana Isabel
A1 Ros, Emili
A1 Diez-Espino, Javier
A1 Babio, Nancy
A1 Fernandez-Carrion, Rebeca
A1 Castañer, Olga
A1 Colom, Antoni
A1 Compañ-Gabucio, Laura
A1 Salaverria-Lete, Itziar
A1 Crespo-Oliva, Edelys
A1 Abete, Itziar
A1 Tomaino, Laura
A1 Casas, Rosa
A1 Fernandez-Garcia, Jose Carlos
A1 Santos-Lozano, Jose Manuel
A1 Sarasa, Iziar
A1 Gamez, Jose M
A1 Garcia-Rios, Jose M Antonio
A1 Martín-Pelaez, Sandra
A1 Ruiz-Canela, Miguel
A1 Diaz-Lopez, Andres
A1 Martinez-Lacruz, Raul
A1 Zomeño, Maria Dolors
A1 Rayo, Elena
A1 Gisbert-Selles, Cristina
A1 Canudas, Silvia
A1 Goday, Albert
A1 García-de-la-Hera, Manoli
K1 Folate intake
K1 Dietary intake
K1 Cardiometabolic risk
K1 Obesity
K1 Overweight
K1 Blood pressure
K1 Glucose metabolism
K1 Triglycerides
AB We examined the association between dietary folate intake and a score of MetS (metabolic syndrome) and its components among older adults at higher cardiometabolic risk participating in the PREDIMED-Plus trial. A cross-sectional analysis with 6633 with overweight/obesity participants with MetS was conducted. Folate intake (per 100 mcg/day and in quintiles) was estimated using a validated food frequency questionnaire. We calculated a MetS score using the standardized values as shown in the formula: [(body mass index + waist-to-height ratio)/2] + [(systolic blood pressure + diastolic blood pressure)/2] + plasma fasting glucose-HDL cholesterol + plasma triglycerides. The MetS score as continuous variable and its seven components were the outcome variables. Multiple robust linear regression using MM-type estimator was performed to evaluate the association adjusting for potential confounders. We observed that an increase in energy-adjusted folate intake was associated with a reduction of MetS score (β for 100 mcg/day = - 0.12; 95% CI: - 0.19 to - 0.05), and plasma fasting glucose (β = - 0.03; 95% CI: - 0.05 to - 0.02) independently of the adherence to Mediterranean diet and other potential confounders. We also found a positive association with HDL-cholesterol (β = 0.07; 95% CI: 0.04-0.10). These associations were also observed when quintiles of energy-adjusted folate intake were used instead. This study suggests that a higher folate intake may be associated with a lower MetS score in older adults, a lower plasma fasting glucose, and a greater HDL cholesterol in high-risk cardio-metabolic subjects.
PB Springer Medizin
YR 2021
FD 2021-03
LK http://hdl.handle.net/10668/16735
UL http://hdl.handle.net/10668/16735
LA en
NO Navarrete-Muñoz EM, Vioque J, Toledo E, Oncina-Canovas A, Martínez-González MÁ, Salas-Salvadó J, et al. Dietary folate intake and metabolic syndrome in participants of PREDIMED-Plus study: a cross-sectional study. Eur J Nutr. 2021 Mar;60(2):1125-1136.
DS RISalud
RD Oct 31, 2025