%0 Journal Article
%A Navarrete-Muñoz, Eva-Maria
%A Vioque, Jesus
%A Toledo, Estefania
%A Oncina-Canovas, Alejando
%A Martinez-Gonzalez, Miguel Angel
%A Salas-Salvado, Jordi
%A Corella, Dolores
%A Fito, Montserrat
%A Romaguera, Dora
%A Alonso-Gomez, Angel M
%A Wärnberg, Julia
%A Martínez, J Alfredo
%A Serra-Majem, Luís
%A Estruch, Ramon
%A Tinahones, Francisco J
%A Lapetra, Jose
%A Pinto, Xavier
%A Tur, Josep A
%A Lopez-Miranda, Jose
%A Bueno-Cavanillas, Aurora
%A Matia-Martin, Pilar
%A Daimiel, Lidia
%A Martin-Sanchez, Vicente 
%A Vidal, Josep
%A de-Cos-Blanco, Ana Isabel
%A Ros, Emili
%A Diez-Espino, Javier
%A Babio, Nancy
%A Fernandez-Carrion, Rebeca
%A Castañer, Olga
%A Colom, Antoni
%A Compañ-Gabucio, Laura
%A Salaverria-Lete, Itziar 
%A Crespo-Oliva, Edelys
%A Abete, Itziar
%A Tomaino, Laura
%A Casas, Rosa
%A Fernandez-Garcia, Jose Carlos
%A Santos-Lozano, Jose Manuel
%A Sarasa, Iziar
%A Gamez, Jose M
%A Garcia-Rios, Jose M Antonio
%A Martín-Pelaez, Sandra
%A Ruiz-Canela, Miguel
%A Diaz-Lopez, Andres
%A Martinez-Lacruz, Raul
%A Zomeño, Maria Dolors
%A Rayo, Elena
%A Gisbert-Selles, Cristina 
%A Canudas, Silvia
%A Goday, Albert
%A García-de-la-Hera, Manoli
%T Dietary folate intake and metabolic syndrome in participants of PREDIMED‑Plus study: a cross‑sectional study.
%D 2021
%U http://hdl.handle.net/10668/16735
%X We examined the association between dietary folate intake and a score of MetS (metabolic syndrome) and its components among older adults at higher cardiometabolic risk participating in the PREDIMED-Plus trial. A cross-sectional analysis with 6633 with overweight/obesity participants with MetS was conducted. Folate intake (per 100 mcg/day and in quintiles) was estimated using a validated food frequency questionnaire. We calculated a MetS score using the standardized values as shown in the formula: [(body mass index + waist-to-height ratio)/2] + [(systolic blood pressure + diastolic blood pressure)/2] + plasma fasting glucose-HDL cholesterol + plasma triglycerides. The MetS score as continuous variable and its seven components were the outcome variables. Multiple robust linear regression using MM-type estimator was performed to evaluate the association adjusting for potential confounders. We observed that an increase in energy-adjusted folate intake was associated with a reduction of MetS score (β for 100 mcg/day = - 0.12; 95% CI: - 0.19 to - 0.05), and plasma fasting glucose (β = - 0.03; 95% CI: - 0.05 to - 0.02) independently of the adherence to Mediterranean diet and other potential confounders. We also found a positive association with HDL-cholesterol (β = 0.07; 95% CI: 0.04-0.10). These associations were also observed when quintiles of energy-adjusted folate intake were used instead. This study suggests that a higher folate intake may be associated with a lower MetS score in older adults, a lower plasma fasting glucose, and a greater HDL cholesterol in high-risk cardio-metabolic subjects.
%K Folate intake
%K Dietary intake
%K Cardiometabolic risk
%K Obesity
%K Overweight
%K Blood pressure
%K Glucose metabolism
%K Triglycerides
%~