RT Journal Article
T1 The lincRNA HOTAIRM1, located in the HOXA genomic region, is expressed in acute myeloid leukemia, impacts prognosis in patients in the intermediate-risk cytogenetic category, and is associated with a distinctive microRNA signature.
A1 Díaz-Beyá, Marina
A1 Brunet, Salut
A1 Nomdedéu, Josep
A1 Pratcorona, Marta
A1 Cordeiro, Anna
A1 Gallardo, David
A1 Escoda, Lourdes
A1 Tormo, Mar
A1 Heras, Inmaculada
A1 Ribera, Josep María
A1 Duarte, Rafael
A1 Queipo de Llano, María Paz
A1 Bargay, Joan
A1 Sampol, Antonia
A1 Nomdedéu, Meritxell
A1 Risueño, Ruth M
A1 Hoyos, Montserrat
A1 Sierra, Jorge
A1 Monzo, Mariano
A1 Navarro, Alfons
A1 Esteve, Jordi
K1 Leucemia mieloide aguda
K1 Leucemia promielocítica aguda
K1 MicroARNs
K1 Pronóstico
K1 ARN no traducido
K1 Recurrencia
K1 Genómica
K1 Humanos
K1 lincRNA
K1 AML
K1 HOTAIRM
K1 HOX
K1 lncRNA
AB Long non-coding RNAs (lncRNAs) are deregulated in several tumors, although their role in acute myeloid leukemia (AML) is mostly unknown.We have examined the expression of the lncRNA HOX antisense intergenic RNA myeloid 1 (HOTAIRM1) in 241 AML patients. We have correlated HOTAIRM1 expression with a miRNA expression profile. We have also analyzed the prognostic value of HOTAIRM1 expression in 215 intermediate-risk AML (IR-AML) patients.The lowest expression level was observed in acute promyelocytic leukemia (P < 0.001) and the highest in t(6;9) AML (P = 0.005). In 215 IR-AML patients, high HOTAIRM1 expression was independently associated with shorter overall survival (OR:2.04;P = 0.001), shorter leukemia-free survival (OR:2.56; P < 0.001) and a higher cumulative incidence of relapse (OR:1.67; P = 0.046). Moreover, HOTAIRM1 maintained its independent prognostic value within the favorable molecular subgroup (OR: 3.43; P = 0.009). Interestingly, HOTAIRM1 was overexpressed in NPM1-mutated AML (P < 0.001) and within this group retained its prognostic value (OR: 2.21; P = 0.01). Moreover, HOTAIRM1 expression was associated with a specific 33-microRNA signature that included miR-196b (P < 0.001). miR-196b is located in the HOX genomic region and has previously been reported to have an independent prognostic value in AML. miR-196b and HOTAIRM1 in combination as a prognostic factor can classify patients as high-, intermediate-, or low-risk (5-year OS: 24% vs 42% vs 70%; P = 0.004).Determination of HOTAIRM1 level at diagnosis provided relevant prognostic information in IR-AML and allowed refinement of risk stratification based on common molecular markers. The prognostic information provided by HOTAIRM1 was strengthened when combined with miR-196b expression. Furthermore, HOTAIRM1 correlated with a 33-miRNA signature.
PB Impact Journals
YR 2015
FD 2015-10-13
LK http://hdl.handle.net/10668/2065
UL http://hdl.handle.net/10668/2065
LA en
NO Díaz-Beyá M, Brunet S, Nomdedéu J, Pratcorona M, Cordeiro A, Gallardo D, et al. The lincRNA HOTAIRM1, located in the HOXA genomic region, is expressed in acute myeloid leukemia, impacts prognosis in patients in the intermediate-risk cytogenetic category, and is associated with a distinctive microRNA signature. Oncotarget. 2015; 6(31):31613-27
NO Journal Article;
DS RISalud
RD Apr 19, 2025