RT Journal Article
T1 Relationship between Physical Activity, Oxidative Stress, and Total Plasma Antioxidant Capacity in Spanish Children from the GENOBOX Study
A1 Llorente-Cantarero, Francisco Jesús
A1 Aguilar-Gómez, Francisco Javier
A1 Leis, Rosaura
A1 Bueno, Gloria
A1 Rupérez, Azahara I.
A1 Anguita-Ruiz, Augusto
A1 Vázquez-Cobela, Rocío
A1 Mesa, María Dolores
A1 Moreno, Luis A.
A1 Gil, Ángel
A1 Aguilera, Concepción María
A1 Gil-Campos, Mercedes
K1 Physical activity
K1 Accelerometry
K1 Oxidative stress
K1 Plasma total antioxidant capacity
K1 8-hydroxy-2′-deoxyguanosine
K1 Isoprostane F2α
K1 Ejercicio físico
K1 Acelerometría
K1 Estrés oxidativo
K1 8-Hidroxi-2'-Desoxicoguanosina
AB The World Health Organization has recommended performing at least 60 min a day of moderate-to-vigorous physical activity (MVPA) and reducing sedentarism in children and adolescents to offer significant health benefits and mitigate health risks. Physical fitness and sports practice seem to improve oxidative stress (OS) status during childhood. However, to our knowledge, there are no data regarding the influence of objectively-measured physical activity (PA) and sedentarism on OS status in children and adolescents. The present study aimed to evaluate the influence of moderate and vigorous PA and sedentarism on OS and plasma total antioxidant capacity (TAC) in a selected Spanish population of 216 children and adolescents from the GENOBOX study. PA (light, moderate, and vigorous) and sedentarism (i.e., sedentary time (ST)) were measured by accelerometry. A Physical Activity-Sedentarism Score (PASS) was developed integrating moderate and vigorous PA and ST levels. Urinary 8-hydroxy-2'-deoxyguanosine (8-OHdG) and isoprostane F2α (F2-IsoPs), as markers of OS, were determined by ELISA; and TAC was estimated by colorimetry using an antioxidant kit. A higher PASS was associated with lower plasma TAC and urinary 8-OHdG and F2-IsoPs, showing a better redox profile. Reduced OS markers (8-OHdG and F2-IsoPs) in children with higher PASS may diminish the need of maintaining high concentrations of antioxidants in plasma during rest to achieve redox homeostasis.
PB MDPI
YR 2021
FD 2021-02-20
LK http://hdl.handle.net/10668/3506
UL http://hdl.handle.net/10668/3506
LA en
NO Llorente-Cantarero FJ, Aguilar-Gomez FJ, Leis R, Bueno G, Ruperez AI, Anguita-Ruiz A, et al. Relationship between Physical Activity, Oxidative Stress, and Total Plasma Antioxidant Capacity in Spanish Children from the GENOBOX Study. Antioxidants. 2021;10(2):320
DS RISalud
RD Apr 6, 2025