RT Journal Article
T1 A Case-Control Analysis of the Impact of Venous Thromboembolic Disease on Quality of Life of Patients with Cancer: Quality of Life in Cancer (Qca) Study.
A1 Marin-Barrera, Lucia
A1 Muñoz-Martin, Andres J
A1 Rios-Herranz, Eduardo
A1 Garcia-Escobar, Ignacio
A1 Beato, Carmen
A1 Font, Carme
A1 Oncala-Sibajas, Estefania
A1 Revuelta-Rodriguez, Alfonso
A1 Areses, Maria Carmen
A1 Rivas-Jimenez, Victor
A1 Moreno-Santos, Maria Angeles
A1 Ballaz-Quincoces, Aitor
A1 Lopez-Saez, Juan-Bosco
A1 Gallego, Iria
A1 Elias-Hernandez, Teresa
A1 Asensio-Cruz, Maria Isabel
A1 Chasco-Eguilaz, Leyre
A1 Garcia-Gonzalez, Gonzalo
A1 Estevez-Garcia, Purificacion
A1 Otero, Remedios
A1 Lima-Alvarez, Jorge
A1 Jara-Palomares, Luis
K1 neoplasm
K1 pulmonary embolism
K1 quality of life
K1 venous thromboembolism
K1 venous thrombosis
AB Although there is published research on the impact of venous thromboembolism (VTE) on quality of life (QoL), this issue has not been thoroughly investigated in patients with cancer-particularly using specific questionnaires. We aimed to examine the impact of acute symptomatic VTE on QoL of patients with malignancies. This was a multicenter, prospective, case-control study conducted in patients with cancer either with (cases) or without (controls) acute symptomatic VTE. Participants completed the EORTC QLQ-C30, EQ-5D-3L, PEmb-QoL, and VEINES-QOL/Sym questionnaires. Statistically significant and clinically relevant differences in terms of global health status were examined. Between 2015 and 2018, we enrolled 425 patients (128 cases and 297 controls; mean age: 60.2 ± 18.4 years). The most common malignancies were gastrointestinal (23.5%) and lung (19.8%) tumors. We found minimally important differences in global health status on the EQ-5D-3L (cases versus controls: 0.55 versus 0.77; mean difference: -0.22) and EORTC QLQ-C30 (47.7 versus 58.4; mean difference: -10.3) questionnaires. There were minimally important differences on the PEmb-QoL questionnaire (44.4 versus 23; mean difference: -21.4) and a significantly worse QoL on the VEINES-QOL/Sym questionnaire (42.7 versus 51.7; mean difference: -9). In conclusion, we showed that acute symptomatic VTE adversely affects the QoL of patients with malignancies.
SN 2072-6694
YR 2019
FD 2019-12-26
LK https://hdl.handle.net/10668/25119
UL https://hdl.handle.net/10668/25119
LA en
DS RISalud
RD Apr 17, 2025