RT Journal Article
T1 Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study.
A1 Moskal, Aurélie
A1 Freisling, Heinz
A1 Byrnes, Graham
A1 Assi, Nada
A1 Fahey, Michael T
A1 Jenab, Mazda
A1 Ferrari, Pietro
A1 Tjønneland, Anne
A1 Petersen, Kristina En
A1 Dahm, Christina C
A1 Hansen, Camilla Plambeck
A1 Affret, Aurélie
A1 Boutron-Ruault, Marie-Christine
A1 Cadeau, Claire
A1 Kühn, Tilman
A1 Katzke, Verena
A1 Iqbal, Khalid
A1 Boeing, Heiner
A1 Trichopoulou, Antonia
A1 Bamia, Christina
A1 Naska, Androniki
A1 Masala, Giovanna
A1 de Magistris, Maria Santucci
A1 Sieri, Sabina
A1 Tumino, Rosario
A1 Sacerdote, Carlotta
A1 Peeters, Petra H
A1 Bueno-de-Mesquita, Bas H
A1 Engeset, Dagrun
A1 Licaj, Idlir
A1 Skeie, Guri
A1 Ardanaz, Eva
A1 Buckland, Genevieve
A1 Castaño, José M Huerta
A1 Quirós, José R
A1 Amiano, Pilar
A1 Molina-Portillo, Elena
A1 Winkvist, Anna
A1 Myte, Robin
A1 Ericson, Ulrika
A1 Sonestedt, Emily
A1 Perez-Cornago, Aurora
A1 Wareham, Nick
A1 Khaw, Kay-Tee
A1 Huybrechts, Inge
A1 Tsilidis, Konstantinos K
A1 Ward, Heather
A1 Gunter, Marc J
A1 Slimani, Nadia
AB Much of the current literature on diet-colorectal cancer (CRC) associations focused on studies of single foods/nutrients, whereas less is known about nutrient patterns. We investigated the association between major nutrient patterns and CRC risk in participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Among 477 312 participants, intakes of 23 nutrients were estimated from validated dietary questionnaires. Using results from a previous principal component (PC) analysis, four major nutrient patterns were identified. Hazard ratios (HRs) and 95% confidence intervals (CIs) were computed for the association of each of the four patterns and CRC incidence using multivariate Cox proportional hazards models with adjustment for established CRC risk factors. During an average of 11 years of follow-up, 4517 incident cases of CRC were documented. A nutrient pattern characterised by high intakes of vitamins and minerals was inversely associated with CRC (HR per 1 s.d.=0.94, 95% CI: 0.92-0.98) as was a pattern characterised by total protein, riboflavin, phosphorus and calcium (HR (1 s.d.)=0.96, 95% CI: 0.93-0.99). The remaining two patterns were not significantly associated with CRC risk. Analysing nutrient patterns may improve our understanding of how groups of nutrients relate to CRC.
YR 2016
FD 2016-10-20
LK http://hdl.handle.net/10668/10550
UL http://hdl.handle.net/10668/10550
LA en
DS RISalud
RD Apr 7, 2025