RT Journal Article
T1 Effect of Trans-Nasal Evaporative Intra-arrest Cooling on Functional Neurologic Outcome in Out-of-Hospital Cardiac Arrest: The PRINCESS Randomized Clinical Trial.
A1 Nordberg, Per
A1 Taccone, Fabio Silvio
A1 Truhlar, Anatolij
A1 Forsberg, Sune
A1 Hollenberg, Jacob
A1 Jonsson, Martin
A1 Cuny, Jerome
A1 Goldstein, Patrick
A1 Vermeersch, Nick
A1 Higuet, Adeline
A1 Jiménes, Francisco Carmona
A1 Ortiz, Fernando Rosell
A1 Williams, Julia
A1 Desruelles, Didier
A1 Creteur, Jacques
A1 Dillenbeck, Emelie
A1 Busche, Caroline
A1 Busch, Hans-Jörg
A1 Ringh, Mattias
A1 Konrad, David
A1 Peterson, Johan
A1 Vincent, Jean-Louis
A1 Svensson, Leif
AB Therapeutic hypothermia may increase survival with good neurologic outcome after cardiac arrest. Trans-nasal evaporative cooling is a method used to induce cooling, primarily of the brain, during cardiopulmonary resuscitation (ie, intra-arrest). To determine whether prehospital trans-nasal evaporative intra-arrest cooling improves survival with good neurologic outcome compared with cooling initiated after hospital arrival. The PRINCESS trial was an investigator-initiated, randomized, clinical, international multicenter study with blinded assessment of the outcome, performed by emergency medical services in 7 European countries from July 2010 to January 2018, with final follow-up on April 29, 2018. In total, 677 patients with bystander-witnessed out-of-hospital cardiac arrest were enrolled. Patients were randomly assigned to receive trans-nasal evaporative intra-arrest cooling (n = 343) or standard care (n = 334). Patients admitted to the hospital in both groups received systemic therapeutic hypothermia at 32°C to 34°C for 24 hours. The primary outcome was survival with good neurologic outcome, defined as Cerebral Performance Category (CPC) 1-2, at 90 days. Secondary outcomes were survival at 90 days and time to reach core body temperature less than 34°C. Among the 677 randomized patients (median age, 65 years; 172 [25%] women), 671 completed the trial. Median time to core temperature less than 34°C was 105 minutes in the intervention group vs 182 minutes in the control group (P  Among patients with out-of-hospital cardiac arrest, trans-nasal evaporative intra-arrest cooling compared with usual care did not result in a statistically significant improvement in survival with good neurologic outcome at 90 days. ClinicalTrials.gov Identifier: NCT01400373.
YR 2019
FD 2019
LK http://hdl.handle.net/10668/13922
UL http://hdl.handle.net/10668/13922
LA en
DS RISalud
RD Apr 8, 2025