RT Journal Article
T1 Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort.
A1 Claeys, Liesel
A1 De Saeger, Sarah
A1 Scelo, Ghislaine
A1 Biessy, Carine
A1 Casagrande, Corinne
A1 Nicolas, Genevieve
A1 Korenjak, Michael
A1 Fervers, Beatrice
A1 Heath, Alicia K
A1 Krogh, Vittorio
A1 Luján-Barroso, Leila
A1 Castilla, Jesus
A1 Ljungberg, Börje
A1 Rodriguez-Barranco, Miguel
A1 Ericson, Ulrika
A1 Santiuste, Carmen
A1 Catalano, Alberto
A1 Overvad, Kim
A1 Brustad, Magritt
A1 Gunter, Marc J
A1 Zavadil, Jiri
A1 De Boevre, Marthe
A1 Huybrechts, Inge
K1 Europe
K1 epidemiology
K1 exposure
K1 external assessment
K1 kidney cancer
K1 mycotoxins
K1 prevention
K1 renal cancer
AB Mycotoxins have been suggested to contribute to a spectrum of adverse health effects in humans, including at low concentrations. The recognition of these food contaminants being carcinogenic, as co-occurring rather than as singularly present, has emerged from recent research. The aim of this study was to assess the potential associations of single and multiple mycotoxin exposures with renal cell carcinoma risk in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Food questionnaire data from the EPIC cohort were matched to mycotoxin food occurrence data compiled by the European Food Safety Authority (EFSA) from European Member States to assess long-term dietary mycotoxin exposures, and to associate these with the risk of renal cell carcinoma (RCC, n = 911 cases) in 450,112 EPIC participants. Potential confounding factors were taken into account. Analyses were conducted using Cox's proportional hazards regression models to compute hazard ratios (HRs) and 95% confidence intervals (95% CIs) with mycotoxin exposures expressed as µg/kg body weight/day. Demographic characteristics differed between the RCC cases and non-cases for body mass index, age, alcohol intake at recruitment, and other dietary factors. In addition, the mycotoxin exposure distributions showed that a large proportion of the EPIC population was exposed to some of the main mycotoxins present in European foods such as deoxynivalenol (DON) and derivatives, fumonisins, Fusarium toxins, Alternaria toxins, and total mycotoxins. Nevertheless, no statistically significant associations were observed between the studied mycotoxins and mycotoxin groups, and the risk of RCC development. These results show an absence of statistically significant associations between long-term dietary mycotoxin exposures and RCC risk. However, these results need to be validated in other cohorts and preferably using repeated dietary exposure measurements. In addition, more occurrence data of, e.g., citrinin and fumonisins in different food commodities and countries in the EFSA database are a prerequisite to establish a greater degree of certainty.
PB MDPI AG
YR 2022
FD 2022-08-25
LK http://hdl.handle.net/10668/21501
UL http://hdl.handle.net/10668/21501
LA en
NO Claeys L, De Saeger S, Scelo G, Biessy C, Casagrande C, Nicolas G, et al. Mycotoxin Exposure and Renal Cell Carcinoma Risk: An Association Study in the EPIC European Cohort. Nutrients. 2022 Aug 30;14(17):3581.
DS RISalud
RD Apr 9, 2025