RT Journal Article
T1 Mediterranean Diet Maintained Platelet Count within a Healthy Range and Decreased Thrombocytopenia-Related Mortality Risk: A Randomized Controlled Trial.
A1 Hernáez, Álvaro
A1 Lassale, Camille
A1 Castro-Barquero, Sara
A1 Ros, Emilio
A1 Tresserra-Rimbau, Anna
A1 Castañer, Olga
A1 Pintó, Xavier
A1 Vázquez-Ruiz, Zenaida
A1 Sorlí, José V
A1 Salas-Salvadó, Jordi
A1 Lapetra, José
A1 Gómez-Gracia, Enrique
A1 Alonso-Gómez, Ángel M
A1 Fiol, Miquel
A1 Serra-Majem, Lluis
A1 Sacanella, Emilio
A1 Razquin, Cristina
A1 Corella, Dolores
A1 Guasch-Ferré, Marta
A1 Cofán, Montserrat
A1 Estruch, Ramón
K1 Mediterranean diet
K1 platelet count
K1 prevention
K1 randomized controlled trial
K1 thrombocytopenia
AB There is little information on the dietary modulation of thrombosis-related risk factors such as platelet count. We aimed to assess the effects of Mediterranean diet (MedDiet) on platelet count and related outcomes in an older population at high cardiovascular risk. In participants of the PREDIMED (PREvención con DIeta MEDiterránea) study, we assessed whether an intervention with a MedDiet enriched with extra-virgin olive oil or nuts, relative to a low-fat control diet, modulated platelet count (n = 4189), the risk of developing thrombocytosis and thrombocytopenia (n = 3086), and the association between these alterations and all-cause mortality (median follow-up time: 3.0 years). Although platelet count increased over time (+0.98·109 units/L·year [95% confidence interval: 0.12; 1.84]), MedDiet interventions moderated this increase, particularly in individuals with near-high baseline count (both MedDiets combined: -3.20·109 units/L·year [-5.81; -0.59]). Thrombocytopenia incidence was lower in the MedDiet interventions (incidence rates: 2.23% in control diet, 0.91% in MedDiets combined; hazard ratio: 0.44 [0.23; 0.83]). Finally, thrombocytopenia was associated with a higher risk of all-cause mortality (hazard ratio: 4.71 [2.69; 8.24]), but this relationship was attenuated in those allocated to MedDiet (p-interaction = 0.018). In brief, MedDiet maintained platelet counts within a healthy range and attenuated platelet-related mortality in older adults at high cardiovascular risk.
YR 2021
FD 2021-02-08
LK http://hdl.handle.net/10668/17142
UL http://hdl.handle.net/10668/17142
LA en
DS RISalud
RD Apr 4, 2025