RT Journal Article
T1 Concentrations of perfluoroalkyl substances in donor breast milk in Southern Spain and their potential determinants.
A1 Serrano, Laura
A1 Iribarne-Duran, Luz Mª
A1 Suarez, Beatriz
A1 Artacho-Cordon, Francisco
A1 Vela-Soria, Fernando
A1 Peña-Caballero, Manuela
A1 Hurtado, Jose A
A1 Olea, Nicolas
A1 Fernandez, Mariana F
A1 Freire, Carmen
K1 Breast milk
K1 Human milk bank
K1 PFOA
K1 PFOS
K1 Perfluoroalkyl substances
K1 Preterm infants
AB Breast milk is considered to offer the best nutrition to infants; however, it may be a source of exposure to environmental chemicals such as perfluoroalkyl compounds (PFAS) for breastfeeding infants. PFAS are a complex group of synthetic chemicals whose high stability has led to their ubiquitous contamination of the environment. To assess the concentrations and profiles of PFAS in breast milk from donors to a human milk bank and explore factors potentially related to this exposure. Pooled milk samples were collected from 82 donors to the Human Milk Bank of the Virgen de las Nieves University Hospital (Granada, Spain). Ultra-high performance liquid chromatography coupled with tandem mass spectrometry (UHPLC-MS/MS) was applied to determine milk concentrations of 11 PFAS, including long-chain and short-chain compounds. A questionnaire was used to collect information on donors' socio-demographic characteristics, lifestyle, diet, and use of personal care products (PCPs). Factors related to individual and total PFAS concentrations were evaluated by multivariate regression analysis. PFAS were detected in 24-100% of breast milk samples. PFHpA was detected in 100% of samples, followed by PFOA (84%), PFNA (71%), PFHxA (66%), and PFTrDA (62%). Perfluorooctane sulfonate (PFOS) was detected in only 34% of donors. The median concentrations ranged from  Several PFAS, including short-chain compounds, are detected in pooled donor milk samples. Breast milk may be an important pathway for the PFAS exposure of breastfed infants, including preterm infants in NICUs. Despite the reduced sample size, these data suggest that various lifestyle factors influence PFAS concentrations, highlighting the use of PCPs.
PB Elsevier GmbH
YR 2021
FD 2021-06-14
LK http://hdl.handle.net/10668/18062
UL http://hdl.handle.net/10668/18062
LA en
NO Serrano L, Iribarne-Durán LM, Suárez B, Artacho-Cordón F, Vela-Soria F, Peña-Caballero M, et al. Concentrations of perfluoroalkyl substances in donor breast milk in Southern Spain and their potential determinants. Int J Hyg Environ Health. 2021 Jul;236:113796.
DS RISalud
RD Apr 11, 2025