RT Journal Article
T1 Dietary Methyl-Group Donor Intake and Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).
A1 Van Puyvelde, Heleen
A1 Papadimitriou, Nikos
A1 Clasen, Joanna
A1 Muller, David
A1 Biessy, Carine
A1 Ferrari, Pietro
A1 Halkjær, Jytte
A1 Overvad, Kim
A1 Tjønneland, Anne
A1 Fortner, Renée T
A1 Katzke, Verena
A1 Schulze, Matthias B
A1 Chiodini, Paolo
A1 Masala, Giovanna
A1 Pala, Valeria
A1 Sacerdote, Carlotta
A1 Tumino, Rosario
A1 Bakker, Marije F
A1 Agudo, Antonio
A1 Ardanaz, Eva
A1 Chirlaque López, María Dolores
A1 Sanchez-Perez, Maria-Jose
A1 Ericson, Ulrika
A1 Gylling, Björn
A1 Karlsson, Therese
A1 Manjer, Jonas
A1 Schmidt, Julie A
A1 Nicolas, Geneviève
A1 Casagrande, Corinne
A1 Weiderpass, Elisabete
A1 Heath, Alicia K
A1 Godderis, Lode
A1 Van Herck, Koen
A1 De Bacquer, Dirk
A1 Gunter, Marc J
A1 Huybrechts, Inge
K1 EPIC
K1 betaine
K1 breast cancer
K1 choline
K1 folate
K1 methionine
AB (1) Background: Methyl-group donors (MGDs), including folate, choline, betaine, and methionine, may influence breast cancer (BC) risk through their role in one-carbon metabolism; (2) Methods: We studied the relationship between dietary intakes of MGDs and BC risk, adopting data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort; (3) Results: 318,686 pre- and postmenopausal women were followed between enrolment in 1992-2000 and December 2013-December 2015. Dietary MGD intakes were estimated at baseline through food-frequency questionnaires. Multivariable Cox proportional hazards regression models were used to quantify the association between dietary intake of MGDs, measured both as a calculated score based on their sum and individually, and BC risk. Subgroup analyses were performed by hormone receptor status, menopausal status, and level of alcohol intake. During a mean follow-up time of 14.1 years, 13,320 women with malignant BC were identified. No associations were found between dietary intakes of the MGD score or individual MGDs and BC risk. However, a potential U-shaped relationship was observed between dietary folate intake and overall BC risk, suggesting an inverse association for intakes up to 350 µg/day compared to a reference intake of 205 µg/day. No statistically significant differences in the associations were observed by hormone receptor status, menopausal status, or level of alcohol intake; (4) Conclusions: There was no strong evidence for an association between MGDs involved in one-carbon metabolism and BC risk. However, a potential U-shaped trend was suggested for dietary folate intake and BC risk. Further research is needed to clarify this association.
PB MDPI AG
YR 2021
FD 2021-05-26
LK http://hdl.handle.net/10668/17927
UL http://hdl.handle.net/10668/17927
LA en
NO Van Puyvelde H, Papadimitriou N, Clasen J, Muller D, Biessy C, Ferrari P, et al. Dietary Methyl-Group Donor Intake and Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). Nutrients. 2021 May 28;13(6):1843.
DS RISalud
RD Apr 12, 2025