%0 Journal Article
%A Van Puyvelde, Heleen
%A Papadimitriou, Nikos
%A Clasen, Joanna
%A Muller, David
%A Biessy, Carine
%A Ferrari, Pietro
%A Halkjær, Jytte
%A Overvad, Kim
%A Tjønneland, Anne
%A Fortner, Renée T
%A Katzke, Verena
%A Schulze, Matthias B
%A Chiodini, Paolo
%A Masala, Giovanna
%A Pala, Valeria
%A Sacerdote, Carlotta
%A Tumino, Rosario
%A Bakker, Marije F
%A Agudo, Antonio
%A Ardanaz, Eva
%A Chirlaque López, María Dolores
%A Sanchez-Perez, Maria-Jose
%A Ericson, Ulrika
%A Gylling, Björn
%A Karlsson, Therese
%A Manjer, Jonas
%A Schmidt, Julie A
%A Nicolas, Geneviève
%A Casagrande, Corinne
%A Weiderpass, Elisabete
%A Heath, Alicia K
%A Godderis, Lode
%A Van Herck, Koen
%A De Bacquer, Dirk
%A Gunter, Marc J
%A Huybrechts, Inge
%T Dietary Methyl-Group Donor Intake and Breast Cancer Risk in the European Prospective Investigation into Cancer and Nutrition (EPIC).
%D 2021
%U http://hdl.handle.net/10668/17927
%X (1) Background: Methyl-group donors (MGDs), including folate, choline, betaine, and methionine, may influence breast cancer (BC) risk through their role in one-carbon metabolism; (2) Methods: We studied the relationship between dietary intakes of MGDs and BC risk, adopting data from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort; (3) Results: 318,686 pre- and postmenopausal women were followed between enrolment in 1992-2000 and December 2013-December 2015. Dietary MGD intakes were estimated at baseline through food-frequency questionnaires. Multivariable Cox proportional hazards regression models were used to quantify the association between dietary intake of MGDs, measured both as a calculated score based on their sum and individually, and BC risk. Subgroup analyses were performed by hormone receptor status, menopausal status, and level of alcohol intake. During a mean follow-up time of 14.1 years, 13,320 women with malignant BC were identified. No associations were found between dietary intakes of the MGD score or individual MGDs and BC risk. However, a potential U-shaped relationship was observed between dietary folate intake and overall BC risk, suggesting an inverse association for intakes up to 350 µg/day compared to a reference intake of 205 µg/day. No statistically significant differences in the associations were observed by hormone receptor status, menopausal status, or level of alcohol intake; (4) Conclusions: There was no strong evidence for an association between MGDs involved in one-carbon metabolism and BC risk. However, a potential U-shaped trend was suggested for dietary folate intake and BC risk. Further research is needed to clarify this association.
%K EPIC
%K betaine
%K breast cancer
%K choline
%K folate
%K methionine
%~