RT Journal Article
T1 Dietary Zinc and Risk of Prostate Cancer in Spain: MCC-Spain Study.
A1 Gutierrez-Gonzalez, Enrique
A1 Castello, Adela
A1 Fernandez-Navarro, Pablo
A1 Castaño-Vinyals, Gemma
A1 Llorca, Javier
A1 Salas, Dolores
A1 Salcedo-Bellido, Inmaculada
A1 Aragones, Nuria
A1 Fernandez-Tardon, Guillermo
A1 Alguacil, Juan
A1 Gracia-Lavedan, Esther
A1 Garcia-Esquinas, Esther
A1 Gomez-Acebo, Ines
A1 Amiano, Pilar
A1 Romaguera, Dora
A1 Kogevinas, Manolis
A1 Pollan, Marina
A1 Perez-Gomez, Beatriz
K1 diet
K1 dietary zinc
K1 genetic susceptibility
K1 prostate cancer
AB Zinc is a key trace element in normal prostate cell metabolism, and is decreased in neoplastic cells. However, the association between dietary zinc and prostate cancer (PC) in epidemiologic studies is a conflicting one. Our aim was to explore this association in an MCC-Spain case-control study, considering tumor aggressiveness and extension, as well as genetic susceptibility to PC. 733 incident cases and 1228 population-based controls were included for this study. Dietary zinc was assessed using a food frequency questionnaire, and genetic susceptibility was assessed with a single nucleotide polymorphisms (SNP)-based polygenic risk score (PRS). The association between zinc intake and PC was evaluated with mixed logistic and multinomial regression models. They showed an increased risk of PC in those with higher intake of zinc (Odds Ratio (OR) tertile 3vs1: 1.39; 95% Confidence interval (CI):1.00⁻1.95). This association was mainly observed in low grade PC (Gleason = 6 RRR tertile 3vs1: 1.76; 95% CI:1.18⁻2.63) as well as in localized tumors (cT1-cT2a RRR tertile 3vs1: 1.40; 95% CI:1.00⁻1.95) and among those with higher PRS (OR tertile 3vs1: 1.50; 95% CI:0.89⁻2.53). In conclusion, a higher dietary zinc intake could increase the risk of low grade and localized tumors. Men with higher genetic susceptibility0020might also have a higher risk of PC associated with this nutrient intake.
PB MDPI AG
YR 2018
FD 2018-12-18
LK http://hdl.handle.net/10668/13347
UL http://hdl.handle.net/10668/13347
LA en
NO Gutiérrez-González E, Castelló A, Fernández-Navarro P, Castaño-Vinyals G, Llorca J, Salas D, et al. Dietary Zinc and Risk of Prostate Cancer in Spain: MCC-Spain Study. Nutrients. 2018 Dec 20;11(1):18.
DS RISalud
RD Apr 12, 2025