RT Generic
T1 Chronotherapy: Circadian Rhythms and Their Influence in Cancer Therapy.
A1 Amiama-Roig, Ana
A1 Verdugo-Sivianes, Eva M
A1 Carnero, Amancio
A1 Blanco, Jose-Ramon
K1 cancer
K1 cancer therapy
K1 chronotherapy
K1 circadian rhythms
AB Living organisms present rhythmic fluctuations every 24 h in their behavior and metabolism to anticipate changes in the environment. These fluctuations are controlled by a very complex molecular mechanism, the circadian clock, that regulates the expression of multiple genes to ensure the right functioning of the body. An individual's circadian system is altered during aging, and this is related to numerous age-associated pathologies and other alterations that could contribute to the development of cancer. Nowadays, there is an increasing interest in understanding how circadian rhythms could be used in the treatment of cancer. Chronotherapy aims to understand the impact that biological rhythms have on the response to a therapy to optimize its action, maximize health benefits and minimize possible adverse effects. Clinical trials so far have confirmed that optimal timing of treatment with chemo or immunotherapies could decrease drug toxicity and increase efficacy. Instead, chronoradiotherapy seems to minimize treatment-related symptoms rather than tumor progression or patient survival. In addition, potential therapeutic targets within the molecular clock have also been identified. Therefore, results of the application of chronotherapy in cancer therapy until now are challenging, feasible, and could be applied to clinical practice to improve cancer treatment without additional costs. However, different limitations and variables such as age, sex, or chronotypes, among others, should be overcome before chronotherapy can really be put into clinical practice.
PB MDPI AG
SN 2072-6694
YR 2022
FD 2022-10-17
LK http://hdl.handle.net/10668/20921
UL http://hdl.handle.net/10668/20921
LA en
NO Amiama-Roig A, Verdugo-Sivianes EM, Carnero A, Blanco JR. Chronotherapy: Circadian Rhythms and Their Influence in Cancer Therapy. Cancers (Basel). 2022 Oct 17;14(20):5071.
DS RISalud
RD Apr 11, 2025