RT Journal Article T1 Long-term consequences of uninephrectomy in male and female rats. A1 Rodríguez-Gómez, Isabel A1 Wangensteen, Rosemary A1 Pérez-Abud, Rocío A1 Quesada, Andrés A1 Moral, Raimundo G Del A1 Osuna, Antonio A1 O'Valle, Francisco A1 Luna, Juan de Dios A1 Vargas, Félix K1 Uninephrectomy K1 renal sodium handling K1 renal injury K1 blood pressure K1 rat K1 Presión Arterial K1 Femenino K1 Riñón K1 Masculino K1 Nefrectomía K1 Estrés Oxidativo K1 Proteinuria K1 Ratas K1 Ratas Wistar K1 Factores Sexuales K1 Sodio AB We investigated the effects of uninephrectomy (UNX) in 6-week-old male and female rats on blood pressure (BP), renal sodium handling, salt sensitivity, oxidative stress, and renal injury over 18 months postsurgery, studying control sham-operated and UNX-operated rats at 6, 12, and 18 months postsurgery, evaluating their renal sodium handling, BP, urinary isoprostanes, N-acetyl-β-D-glucosaminidase, and proteinuria before and after a 2-week high-salt intake period. At 18 months, plasma variables were measured and kidney samples were taken for the analysis of renal morphology and tissue variables. BP was increased at 6 months in male UNX rats versus controls and at 12 and 18 months in both male and female UNX rats and was increased in male versus female UNX groups at 18 months. UNX did not affect water and sodium excretion under basal conditions and after the different test in male and female rats at different ages. However, the renal function curve was shifted to the right in both male and female UNX rats. High-salt intake increased BP in both UNX groups at 6, 12, and 18 months and in the female control group at 18 months, and it increased proteinuria, N-acetyl-β-D-glucosaminidase, and isoprostanes in both UNX groups throughout the study. Renal lesions at 18 months were more severe in male versus female UNX rats. In summary, long-term UNX increased the BP, creatinine, proteinuria, pathological signs of renal injury, and salt sensitivity. Earlier BP elevation was observed and morphological lesions were more severe in male than in female UNX rats. PB American Heart Association SN 0194-911X YR 2012 FD 2012-12 LK http://hdl.handle.net/10668/1327 UL http://hdl.handle.net/10668/1327 LA en NO Rodríguez-Gómez I, Wangensteen R, Pérez-Abud R, Quesada A, Del Moral RG, Osuna A, et al. Long-term consequences of uninephrectomy in male and female rats. Hypertension. 2012 ; 60(6):1458-63 NO Journal Article; Research Support, Non-U.S. Gov't; DS RISalud RD Apr 12, 2025