RT Journal Article
T1 Prognostic Implication of Non-Obstructive Coronary Lesions: A New Classification in Different Settings.
A1 Rodriguez-Capitan, Jorge
A1 Sanchez-Perez, Andres
A1 Ballesteros-Pradas, Sara
A1 Millan-Gomez, Mercedes
A1 Cardenal-Piris, Rosa
A1 Oneto-Fernandez, Manuel
A1 Gutierrez-Alonso, Lola
A1 Rivera-Lopez, Ricardo
A1 Guisado-Rasco, Agustin
A1 Cano-Garcia, Macarena
A1 Gutierrez-Bedmar, Mario
A1 Jimenez-Navarro, Manuel
K1 acute coronary syndrome
K1 coronary angiography
K1 coronary artery disease
K1 diabetes mellitus
K1 sex
AB The clinical significance of non-obstructive coronary artery disease is the subject of debate. Our objective was to evaluate the long-term cardiovascular prognosis associated with non-obstructive coronary artery disease in patients undergoing coronary angiography, and to conduct a stratification by sex, diabetes, and clinical indication. We designed a multi-centre retrospective longitudinal observational study of 3265 patients that were classified into three groups: normal coronary arteries(lesion <20%, 1426 patients), non-obstructive coronary artery disease (20–50%, 643 patients), and obstructive coronary artery disease (>70%, 1196 patients). During a mean follow-up of 43 months, we evaluated a combined cardiovascular event: acute myocardial infarction, stroke, hospitalization for heart failure, or cardiovascular death. Multivariable-adjusted Cox  proportional hazard models showed a worse prognosis in patients with non-obstructive coronary artery disease, in comparison with patients of normal coronary arteries group, in the total population (hazard ratio 1.72, 95% confidence interval 1.23–2.39; p for trend <0.001), in non-diabetics (hazard ratio 2.12, 95% confidence interval: 1.40–3.22), in women (hazard ratio 1.75, 95% confidence interval 1.10–2.77), and after acute coronary syndrome (hazard ratio 2.07, 95% confidence interval 1.25–3.44). In conclusion, non-obstructive coronary artery disease is associated with an impaired long-term cardiovascular prognosis. This association held for non-diabetics, women, and after acute coronary syndrome.
PB MDPI AG
SN 2077-0383
YR 2021
FD 2021-04-22
LK http://hdl.handle.net/10668/17704
UL http://hdl.handle.net/10668/17704
LA en
NO Rodríguez-Capitán J, Sánchez-Pérez A, Ballesteros-Pradas S, Millán-Gómez M, Cardenal-Piris R, Oneto-Fernández M, et al. Prognostic Implication of Non-Obstructive Coronary Lesions: A New Classification in Different Settings. J Clin Med. 2021 Apr 25;10(9):1863.
DS RISalud
RD Apr 7, 2025