%0 Journal Article
%A Rodriguez-Capitan, Jorge
%A Sanchez-Perez, Andres
%A Ballesteros-Pradas, Sara
%A Millan-Gomez, Mercedes
%A Cardenal-Piris, Rosa
%A Oneto-Fernandez, Manuel
%A Gutierrez-Alonso, Lola
%A Rivera-Lopez, Ricardo
%A Guisado-Rasco, Agustin
%A Cano-Garcia, Macarena
%A Gutierrez-Bedmar, Mario
%A Jimenez-Navarro, Manuel
%T Prognostic Implication of Non-Obstructive Coronary Lesions: A New Classification in Different Settings.
%D 2021
%@ 2077-0383
%U http://hdl.handle.net/10668/17704
%X The clinical significance of non-obstructive coronary artery disease is the subject of debate. Our objective was to evaluate the long-term cardiovascular prognosis associated with non-obstructive coronary artery disease in patients undergoing coronary angiography, and to conduct a stratification by sex, diabetes, and clinical indication. We designed a multi-centre retrospective longitudinal observational study of 3265 patients that were classified into three groups: normal coronary arteries(lesion <20%, 1426 patients), non-obstructive coronary artery disease (20–50%, 643 patients), and obstructive coronary artery disease (>70%, 1196 patients). During a mean follow-up of 43 months, we evaluated a combined cardiovascular event: acute myocardial infarction, stroke, hospitalization for heart failure, or cardiovascular death. Multivariable-adjusted Cox  proportional hazard models showed a worse prognosis in patients with non-obstructive coronary artery disease, in comparison with patients of normal coronary arteries group, in the total population (hazard ratio 1.72, 95% confidence interval 1.23–2.39; p for trend <0.001), in non-diabetics (hazard ratio 2.12, 95% confidence interval: 1.40–3.22), in women (hazard ratio 1.75, 95% confidence interval 1.10–2.77), and after acute coronary syndrome (hazard ratio 2.07, 95% confidence interval 1.25–3.44). In conclusion, non-obstructive coronary artery disease is associated with an impaired long-term cardiovascular prognosis. This association held for non-diabetics, women, and after acute coronary syndrome.
%K acute coronary syndrome
%K coronary angiography
%K coronary artery disease
%K diabetes mellitus
%K sex
%~