RT Journal Article
T1 Low Percentage of Vegetable Fat in Red Blood Cells Is Associated with Worse Glucose Metabolism and Incidence of Type 2 Diabetes.
A1 Chiva-Blanch, Gemma
A1 Giro, Oriol
A1 Cofan, Montserrat
A1 Calle-Pascual, Alfonso L
A1 Delgado, Elias
A1 Gomis, Ramon
A1 Jimenez, Amanda
A1 Franch-Nadal, Josep
A1 Rojo Martinez, Gemma
A1 Ortega, Emilio
K1 Alpha-linolenic acid
K1 Fatty acids
K1 Linoleic acid
K1 Omega-3 fatty acids
K1 Type 2 diabetes
K1 Worse of glucose metabolism
AB The identification of nutritional patterns associated with the development of type 2 diabetes (T2D) might help lead the way to a more efficient and personalized nutritional intervention. Our study is aimed at evaluating the association between fatty acids (FA) in red blood cell (RBC) membranes, as a quantitative biomarker of regular dietary fat intake, and incident type 2 diabetes in a Spanish population. We included 1032 adult Spaniards (57% women, age 49 ± 15 years, 18% prediabetes), without diabetes at study entry, from the Di@bet.es cohort. Incident diabetes was diagnosed at the end of the study follow-up. The FA percentage in RBC was determined at baseline by gas chromatography. Participants were followed on average 7.5 ± 0.6 years. Lower percentages of linoleic acid (LA), α-linolenic (ALA), and eicosapentaenoic acid (EPA), and higher percentages of docosahexaenoic acid (DHA) in RBC membranes were associated, independently of classical risk factors, with worse glucose metabolism at the end of the study follow-up. In addition, higher percentages of ALA and EPA, and moderate percentages of DHA, were associated with lower risk of diabetes. No significant associations were found for LA and diabetes risk. Dietary patterns rich in vegetables are independently associated with lower risk of both deterioration of glucose regulation and incident diabetes, and should be reinforced for the prevention of diabetes.
PB MDPI
YR 2022
FD 2022-03-25
LK http://hdl.handle.net/10668/21465
UL http://hdl.handle.net/10668/21465
LA en
NO Chiva-Blanch G, Giró O, Cofán M, Calle-Pascual AL, Delgado E, Gomis R, et al. Low Percentage of Vegetable Fat in Red Blood Cells Is Associated with Worse Glucose Metabolism and Incidence of Type 2 Diabetes. Nutrients. 2022 Mar 25;14(7):1368
DS RISalud
RD Jul 29, 2025