RT Journal Article T1 Low Percentage of Vegetable Fat in Red Blood Cells Is Associated with Worse Glucose Metabolism and Incidence of Type 2 Diabetes. A1 Chiva-Blanch, Gemma A1 Giro, Oriol A1 Cofan, Montserrat A1 Calle-Pascual, Alfonso L A1 Delgado, Elias A1 Gomis, Ramon A1 Jimenez, Amanda A1 Franch-Nadal, Josep A1 Rojo Martinez, Gemma A1 Ortega, Emilio K1 Alpha-linolenic acid K1 Fatty acids K1 Linoleic acid K1 Omega-3 fatty acids K1 Type 2 diabetes K1 Worse of glucose metabolism AB The identification of nutritional patterns associated with the development of type 2 diabetes (T2D) might help lead the way to a more efficient and personalized nutritional intervention. Our study is aimed at evaluating the association between fatty acids (FA) in red blood cell (RBC) membranes, as a quantitative biomarker of regular dietary fat intake, and incident type 2 diabetes in a Spanish population. We included 1032 adult Spaniards (57% women, age 49 ± 15 years, 18% prediabetes), without diabetes at study entry, from the Di@bet.es cohort. Incident diabetes was diagnosed at the end of the study follow-up. The FA percentage in RBC was determined at baseline by gas chromatography. Participants were followed on average 7.5 ± 0.6 years. Lower percentages of linoleic acid (LA), α-linolenic (ALA), and eicosapentaenoic acid (EPA), and higher percentages of docosahexaenoic acid (DHA) in RBC membranes were associated, independently of classical risk factors, with worse glucose metabolism at the end of the study follow-up. In addition, higher percentages of ALA and EPA, and moderate percentages of DHA, were associated with lower risk of diabetes. No significant associations were found for LA and diabetes risk. Dietary patterns rich in vegetables are independently associated with lower risk of both deterioration of glucose regulation and incident diabetes, and should be reinforced for the prevention of diabetes. PB MDPI YR 2022 FD 2022-03-25 LK http://hdl.handle.net/10668/21465 UL http://hdl.handle.net/10668/21465 LA en NO Chiva-Blanch G, Giró O, Cofán M, Calle-Pascual AL, Delgado E, Gomis R, et al. Low Percentage of Vegetable Fat in Red Blood Cells Is Associated with Worse Glucose Metabolism and Incidence of Type 2 Diabetes. Nutrients. 2022 Mar 25;14(7):1368 DS RISalud RD Jul 6, 2025