TY - JOUR AU - Jurado-Escobar, Raquel AU - Doña, Inmaculada AU - Triano-Cornejo, José AU - Perkins, James R. AU - Pérez-Sánchez, Natalia AU - Testera-Montes, Almudena AU - Labella, Marina AU - Bartra, Joan AU - Laguna, José J. AU - Estravís, Miguel AU - Agúndez, José A.G. AU - Torres, María J. AU - Cornejo-García, José A. PY - 2021 DO - 10.3389/fphar.2021.667824 UR - http://hdl.handle.net/10668/3525 T2 - Frontiers in Pharmacology AB - Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the main triggers of drug hypersensitivity reactions, probably due to their high consumption worldwide. The most frequent type of NSAID hypersensitivity is NSAID cross-hypersensitivity, in which... LA - en PB - Frontiers KW - NSAID cross-hypersensitivity KW - Urticaria/angioedema KW - Cytosolic phospholipase A2 KW - Polymorphisms KW - Arachidomic acid KW - Medical Subject Headings::Chemicals and Drugs::Lipids::Fatty Acids::Fatty Acids, Unsaturated::Arachidonic Acids::Arachidonic Acid KW - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Multienzyme Complexes::Prostaglandin-Endoperoxide Synthases KW - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide KW - Medical Subject Headings::Phenomena and Processes::Chemical Phenomena::Chemical Processes::Hydrolysis KW - Medical Subject Headings::Diseases::Cardiovascular Diseases::Vascular Diseases::Angioedema KW - Medical Subject Headings::Chemicals and Drugs::Enzymes and Coenzymes::Enzymes::Hydrolases::Esterases::Carboxylic Ester Hydrolases::Phospholipases::Phospholipases A::Phospholipases A2 KW - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antirheumatic Agents TI - Genetic Variants in Cytosolic Phospholipase A2 Associated With Nonsteroidal Anti-Inflammatory Drug-Induced Acute Urticaria/Angioedema TY - research article ER -