RT Journal Article T1 Theories of Change and Mediators of Psychotherapy Effectiveness in Adolescents With Externalising Behaviours: A Systematic Review. A1 Mestre, José M A1 Taubner, Svenja A1 Mota, Catarina Pinheiro A1 Rangel Henriques, Margarida A1 Saliba, Andrea A1 Heinonen, Erkki A1 Ramos, Sara A1 Moreno-Peral, Patricia A1 Volkert, Jana A1 Adler, Asta A1 Barkauskiene, Rasa A1 Conejo-Cerón, Sonia A1 Di Giacomo, Dina A1 Ioannou, Yianna A1 Mucha Vieira, Filipa A1 Røssberg, Jan Ivar A1 Sales, Célia M D A1 Schmidt, Stefanie J A1 Stepisnik Perdih, Tjasa A1 Ulberg, Randi A1 Protić, Sonja K1 adolescence K1 distal and proximal factors K1 externalising behaviours K1 externalising disorders K1 psychological-treatment effectiveness K1 systematic review K1 therapeutic mediation AB Externalising behaviours are becoming a remarkably prevalent problem during adolescence, often precipitating both externalising and internalising disorders in later adulthood. Psychological treatments aim to increase the social functioning of adolescents in order for them to live a more balanced life and prevent these negative trajectories. However, little is known of the intervening variables and mediators involved in these treatments' change mechanisms. We conducted a systematic review, exploring the available evidence on mediators of psychological treatments for externalising behaviours and symptoms amongst adolescents (10 to 19 years old). A systematic search was performed on Medline and PsycINFO databases, which identified studies from inception to February 23, 2020. Eligible studies included randomised controlled trials that enrolled adolescents with externalising symptoms and behaviours as, at least, one of the primary outcomes. A group of 20 reviewers from the COST-Action TREATme (CA16102) were divided into 10 pairs. Each pair independently screened studies for inclusion, extracted information from the included studies, and assessed the methodological quality of the included studies and the requirements for mediators, following Kazdin's criteria. Risk of bias of RCTs was assessed by the Mixed Methods Appraisal Tool. Extracted data from the included studies were reported using a narrative synthesis. Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines (PRISMA), after removing duplicates, 3,660 articles were screened. Disagreements were resolved by consensus. In a second stage, 965 full-text articles were assessed for eligibility. A total of 14 studies fulfilled all inclusion criteria. The majority were related to systemic psychological treatment approaches. Two types of mediators were identified as potentially being involved in the mechanisms of change for better social improvements of adolescents: to increase healthier parent-adolescent relationships and parental discipline. However, there were significant and non-significant results amongst the same mediators, which led to discussing the results tentatively. Family variables were found to be the largest group of investigated mediators, followed by relational, behavioural, and emotional variables. No cognitive or treatment-specific mediators were identified. Both adequate behavioural control of adolescents' peer behaviour and a better positive balance in their relationships with their parents seemed to buffer the effects of externalising behaviours in adolescents. Several methodological limitations concerning mediation testing design, outcome measures, and mediator selection have been identified. Ethical approval was not required. PROSPERO registration number: CRD42021231835. SN 1664-0640 YR 2022 FD 2022-01-14 LK http://hdl.handle.net/10668/20734 UL http://hdl.handle.net/10668/20734 LA en DS RISalud RD Apr 7, 2025