RT Journal Article
T1 Neurotoxicity by mercury is not associated with autism spectrum disorders in Spanish children.
A1 Gil-Hernandez, Fernando
A1 Gomez-Fernandez, Antonio R
A1 la Torre-Aguilar, Maria Josede
A1 Perez-Navero, Juan L
A1 Flores-Rojas, Katherine
A1 Martin-Borreguero, Pilar
A1 Gil-Campos, Mercedes
K1 Autism spectrum disorder
K1 Children
K1 Hair
K1 Mercury
K1 Neurotoxicity
K1 Urine
AB The pathophysiological etiologies related with the development of Autism Spectrum Disorders (ASD) remain controversial. Different authors have studied neurotoxins such as mercury (Hg) and their relationship with ADS. The objective of this study was to assess the levels of Hg in hair in a group of ASD children (chronic exposure) and in urinary excretion (acute exposure), in comparison to a healthy group. A case-control study was conducted in Spanish children. We compared 54 ASD children (aged 2-6) with no other associated pathology to a normally-developing control group (54 subjects). There were no differences in urine (p:0.631) and hair (p:1.000) samples percentages below the limits of detection between the control and the ASD groups, and also between patients in the regression ASD subgroup (AMR) (p:0.08) and the non-regression ASD subgroup (ANMR) (p:0.705). When the analysis was adjusted for age and sex, the differences between Hg levels maintained not significant. There were no correlations between Hg concentrations in the ASD group as a whole (p: 0.739), or when they were subdivided into ASD-AMR (p: 0.739) and ASD-ANMR (p: 0.363). The present study shows no evidence in our geographical area to support an association between mercury neurotoxicity and the etiopathogenesis of ASD.
PB BioMed Central
YR 2020
FD 2020-01-29
LK http://hdl.handle.net/10668/15097
UL http://hdl.handle.net/10668/15097
LA en
NO Gil-Hernández F, Gómez-Fernández AR, la Torre-Aguilar MJ, Pérez-Navero JL, Flores-Rojas K, Martín-Borreguero P, et al. Neurotoxicity by mercury is not associated with autism spectrum disorders in Spanish children. Ital J Pediatr. 2020 Feb 12;46(1):19
DS RISalud
RD Jun 1, 2025