RT Journal Article
T1 Use of human pluripotent stem cell-derived cells for neurodegenerative disease modeling and drug screening platform.
A1 Garcia-Leon, Juan Antonio
A1 Vitorica, Javier
A1 Gutierrez, Antonia
K1 Alzheimer’s disease
K1 CRISPR-Cas9
K1 Huntington’s disease
K1 Parkinson’s disease
K1 amyotrophic lateral sclerosis
K1 disease modeling
K1 drug screening
K1 hiPSCs
K1 human-induced pluripotent stem cells
K1 multiple sclerosis
K1 neurodegenerative disease
AB Most neurodegenerative diseases are characterized by a complex and mostly still unresolved pathology. This fact, together with the lack of reliable disease models, has precluded the development of effective therapies counteracting the disease progression. The advent of human pluripotent stem cells has revolutionized the field allowing the generation of disease-relevant neural cell types that can be used for disease modeling, drug screening and, possibly, cell transplantation purposes. In this Review, we discuss the applications of human pluripotent stem cells, the development of efficient protocols for the derivation of the different neural cells and their applicability for robust in vitro disease modeling and drug screening platforms for most common neurodegenerative conditions.
YR 2019
FD 2019-06-04
LK http://hdl.handle.net/10668/14074
UL http://hdl.handle.net/10668/14074
LA en
DS RISalud
RD Apr 6, 2025