RT Journal Article
T1 The Antioxidant Activity of Thymus serpyllum Extract Protects against the Inflammatory State and Modulates Gut Dysbiosis in Diet-Induced Obesity in Mice.
A1 Ruiz-Malagon, Antonio Jesus
A1 Rodriguez-Sojo, Maria Jesus
A1 Hidalgo-Garcia, Laura
A1 Molina-Tijeras, Jose Alberto
A1 Garcia, Federico
A1 Pischel, Ivo
A1 Romero, Miguel
A1 Duarte, Juan
A1 Diez-Echave, Patricia
A1 Rodriguez-Cabezas, Maria Elena
A1 Rodriguez-Nogales, Alba
A1 Galvez, Julio
K1 Thymus serpyllum
K1 anti-inflammatory
K1 antioxidant
K1 gut microbiota
K1 high fat diet
K1 obesity
AB Nowadays, there is an increasing interest in alternative therapies in the treatment of metabolic syndrome that combine efficacy and safety profiles. Therefore, this study aimed to evaluate the effect of an extract of Thymus serpyllum, containing rosmarinic acid, on high-fat diet (HFD)-induced obesity mice, highlighting the impact of its antioxidant activity on the inflammatory status and gut dysbiosis. The extract was administered daily (50, 100 and 150 mg/kg) in HFD-fed mice. The treatment reduced body weight gain, glucose and lipid metabolic profiles. Moreover, the extract ameliorated the inflammatory status, with the c-Jun N-terminal kinases (JUNK) pathway being involved, and showed a significant antioxidant effect by the reduction of radical scavenging activity and the mitigation of lipid peroxidation. Moreover, the extract was able to modulate the altered gut microbiota, restoring microbial richness and diversity, and augmenting the counts of short-chain fatty acid producing bacteria, which have been associated with the maintenance of gut permeability and weight regulation. In conclusion, the antioxidant activity of Thymus serpyllum extract displayed a positive impact on obesity and its metabolic alterations, also reducing systemic inflammation. These effects may be mediated by modulation of the gut microbiota.
PB MDPI AG
SN 2076-3921
YR 2022
FD 2022-05-24
LK http://hdl.handle.net/10668/20782
UL http://hdl.handle.net/10668/20782
LA en
NO Ruiz-Malagón AJ, Rodríguez-Sojo MJ, Hidalgo-García L, Molina-Tijeras JA, García F, et al. The Antioxidant Activity of Thymus serpyllum Extract Protects against the Inflammatory State and Modulates Gut Dysbiosis in Diet-Induced Obesity in Mice. Antioxidants (Basel). 2022 May 28;11(6):1073.
DS RISalud
RD Apr 16, 2025