RT Journal Article
T1 Widening control of fin inter-rays in zebrafish and inferences about actinopterygian fins.
A1 Murciano, Carmen
A1 Cazorla-Vázquez, Salvador
A1 Gutiérrez, Javier
A1 Hijano, Juan Antonio
A1 Ruiz-Sánchez, Josefa
A1 Mesa-Almagro, Laura
A1 Martín-Reyes, Flores
A1 Fernández, Tahía Diana
A1 Marí-Beffa, Manuel
K1 knck5b
K1 actinopterygii
K1 euteleostei
K1 evo-devo
K1 fibroblast growth factor receptor 1
K1 fin regeneration
K1 inter-ray
AB The amputation of a teleost fin rapidly triggers an intricate maze of hierarchically regulated signalling processes which ultimately reconstruct the diverse tissues of the appendage. Whereas the generation of the fin pattern along the proximodistal axis brings with it several well-known developmental regulators, the mechanisms by which the fin widens along its dorsoventral axis remain poorly understood. Utilizing the zebrafish as an experimental model of fin regeneration and studying more than 1000 actinopterygian species, we hypothesized a connection between specific inter-ray regulatory mechanisms and the morphological variability of inter-ray membranes found in nature. To tackle these issues, both cellular and molecular approaches have been adopted and our results suggest the existence of two distinguishable inter-ray areas in the zebrafish caudal fin, a marginal and a central region. The present work associates the activity of the cell membrane potassium channel kcnk5b, the fibroblast growth factor receptor 1 and the sonic hedgehog pathway to the control of several cell functions involved in inter-ray wound healing or dorsoventral regeneration of the zebrafish caudal fin. This ray-dependent regulation controls cell migration, cell-type patterning and gene expression. The possibility that modifications of these mechanisms are responsible for phenotypic variations found in euteleostean species, is discussed.
YR 2018
FD 2018-02-14
LK http://hdl.handle.net/10668/12133
UL http://hdl.handle.net/10668/12133
LA en
DS RISalud
RD Apr 11, 2025