RT Journal Article
T1 The DESCARTES-Nantes survey of kidney transplant recipients displaying clinical operational tolerance identifies 35 new tolerant patients and 34 almost tolerant patients.
A1 Massart, Annick
A1 Pallier, Annaïck
A1 Pascual, Julio
A1 Viklicky, Ondrej
A1 Budde, Klemens
A1 Spasovski, Goce
A1 Klinger, Marian
A1 Sever, Mehmet Sukru
A1 Sørensen, Søren Schwartz
A1 Hadaya, Karine
A1 Oberbauer, Rainer
A1 Dudley, Christopher
A1 De Fijter, Johan W
A1 Yussim, Alexander
A1 Hazzan, Marc
A1 Wekerle, Thomas
A1 Berglund, David
A1 De Biase, Consuelo
A1 Pérez-Sáez, María José
A1 Mühlfeld, Anja
A1 Orlando, Giuseppe
A1 Clemente, Katia
A1 Lai, Quirino
A1 Pisani, Francesco
A1 Kandus, Aljosa
A1 Baas, Marije
A1 Bemelman, Frederike
A1 Ponikvar, Jadranka Buturovic
A1 Mazouz, Hakim
A1 Stratta, Piero
A1 Subra, Jean-François
A1 Villemain, Florence
A1 Hoitsma, Andries
A1 Braun, Laura
A1 Cantarell, Maria Carmen
A1 Colak, Hulya
A1 Courtney, Aisling
A1 Frasca, Giovanni Maria
A1 Howse, Matthew
A1 Naesens, Maarten
A1 Reischig, Tomas
A1 Serón, Daniel
A1 Seyahi, Nurhan
A1 Tugmen, Cem
A1 Alonso Hernandez, Angel
A1 Beňa, Luboslav
A1 Biancone, Luigi
A1 Cuna, Vania
A1 Díaz-Corte, Carmen
A1 Dufay, Alexandre
A1 Gaasbeek, André
A1 Garnier, Arnaud
A1 Gatault, Philippe
A1 Gentil Govantes, Miguel Angel
A1 Glowacki, François
A1 Gross, Oliver
A1 Hurault de Ligny, Bruno
A1 Huynh-Do, Uyen
A1 Janbon, Bénédicte
A1 Jiménez Del Cerro, Luis Antonio
A1 Keller, Frieder
A1 La Manna, Gaetano
A1 Lauzurica, Ricardo
A1 Le Monies De Sagazan, Hervé
A1 Thaiss, Friedrich
A1 Legendre, Christophe
A1 Martin, Séverine
A1 Moal, Marie-Christine
A1 Noël, Christian
A1 Pillebout, Evangeline
A1 Piredda, Gian Benedetto
A1 Puga, Ana Ramírez
A1 Sulowicz, Wladyslaw
A1 Tuglular, Serhan
A1 Prokopova, Michaela
A1 Chesneau, Mélanie
A1 Le Moine, Alain
A1 Guérif, Pierrick
A1 Soulillou, Jean-Paul
A1 Abramowicz, Marc
A1 Giral, Magali
A1 Racapé, Judith
A1 Maggiore, Umberto
A1 Brouard, Sophie
A1 Abramowicz, Daniel
K1 frequency
K1 graft survival
K1 kidney transplantation
K1 minimally immunosuppressed patients
K1 operational tolerance
AB Kidney recipients maintaining a prolonged allograft survival in the absence of immunosuppressive drugs and without evidence of rejection are supposed to be exceptional. The ERA-EDTA-DESCARTES working group together with Nantes University launched a European-wide survey to identify new patients, describe them and estimate their frequency for the first time. Seventeen coordinators distributed a questionnaire in 256 transplant centres and 28 countries in order to report as many 'operationally tolerant' patients (TOL; defined as having a serum creatinine  One hundred and forty-seven questionnaires were returned and we identified 66 TOL (61 with complete data) and 34 MIS patients. Of the 61 TOL patients, 26 were previously described by the Nantes group and 35 new patients are presented here. Most of them were noncompliant patients. At data collection, 31/35 patients were alive and 22/31 still operationally tolerant. For the remaining 9/31, 2 were restarted on immunosuppressive drugs and 7 had rising creatinine of whom 3 resumed dialysis. Considering all patients, 10-year death-censored graft survival post-immunosuppression weaning reached 85% in TOL patients and 100% in MIS patients. With 218 913 kidney recipients surveyed, cumulative incidences of operational tolerance and almost tolerance were estimated at 3 and 1.5 per 10 000 kidney recipients, respectively. In kidney transplantation, operational tolerance and almost tolerance are infrequent findings associated with excellent long-term death-censored graft survival.
YR 2016
FD 2016-01-12
LK http://hdl.handle.net/10668/9729
UL http://hdl.handle.net/10668/9729
LA en
DS RISalud
RD Apr 6, 2025