RT Journal Article
T1 Endometriosis: alternative methods of medical treatment.
A1 Muñoz-Hernando, Leticia
A1 Muñoz-Gonzalez, Jose L
A1 Marqueta-Marques, Laura
A1 Alvarez-Conejo, Carmen
A1 Tejerizo-García, Álvaro
A1 Lopez-Gonzalez, Gregorio
A1 Villegas-Muñoz, Emilia
A1 Martin-Jimenez, Angel
A1 Jiménez-López, Jesús S
K1 Pharmacological treatment options
K1 Aromatase inhibitors
K1 GnRH antagonists
K1 Selective progesterone receptor modulators
K1 Anti-TNF-α
K1 Endometrial tissue
K1 Antiangiogenic factors
K1 Hormonal treatments
K1 Inductores de la angiogénesis
K1 Inhibidores de la aromatasa
K1 Endometriosis
K1 Estrógenos
K1 Femenino
K1 Hormona liberadora de gonadotropinas
K1 Dolor
K1 Resultado del tratamiento
AB Endometriosis is an inflammatory estrogen-dependent disease defined by the presence of endometrial glands and stroma at extrauterine sites. The main purpose of endometriosis management is alleviating pain associated to the disease. This can be achieved surgically or medically, although in most women a combination of both treatments is required. Long-term medical treatment is usually needed in most women. Unfortunately, in most cases, pain symptoms recur between 6 months and 12 months once treatment is stopped. The authors conducted a literature search for English original articles, related to new medical treatments of endometriosis in humans, including articles published in PubMed, Medline, and the Cochrane Library. Keywords included "endometriosis" matched with "medical treatment", "new treatment", "GnRH antagonists", "Aromatase inhibitors", "selective progesterone receptor modulators", "anti-TNF α", and "anti-angiogenic factors". Hormonal treatments currently available are effective in the relief of pain associated to endometriosis. Among new hormonal drugs, association to aromatase inhibitors could be effective in the treatment of women who do not respond to conventional therapies. GnRH antagonists are expected to be as effective as GnRH agonists, but with easier administration (oral). There is a need to find effective treatments that do not block the ovarian function. For this purpose, antiangiogenic factors could be important components of endometriosis therapy in the future. Upcoming researches and controlled clinical trials should focus on these drugs.
PB Dove Medical Press
YR 2015
FD 2015-06-11
LK http://hdl.handle.net/10668/2143
UL http://hdl.handle.net/10668/2143
LA en
NO Muñoz-Hernando L, Muñoz-Gonzalez JL, Marqueta-Marques L, Alvarez-Conejo C, Tejerizo-García Á, Lopez-Gonzalez G, et al. Endometriosis: alternative methods of medical treatment. Int J Womens Health. 2015; 7:595-603
NO Journal Article;
DS RISalud
RD Apr 6, 2025