RT Journal Article
T1 Palmitoleoylethanolamide Is an Efficient Anti-Obesity Endogenous Compound: Comparison with Oleylethanolamide in Diet-Induced Obesity
A1 Tovar, Rubén
A1 Gavito, Ana Luisa
A1 Vargas, Antonio
A1 Soverchia, Laura
A1 Hernandez-Folgado, Laura
A1 Jagerovic, Nadine
A1 Baixeras, Elena
A1 Ciccocioppo, Roberto
A1 Rodríguez de Fonseca, Fernando
A1 Decara, Juan
K1 N-acylethanolamine
K1 Palmitoleylethanolamide
K1 Monounsaturated fatty acids
K1 Palmitoleic acid
K1 Oleylethanolamide
K1 Oleic acid
K1 Peroxisome proliferator receptor alpha
K1 Cannabinoid receptors type 1
K1 Hypercaloric cafeteria diet
K1 Obesity
K1 Inflammation
K1 Body weight
K1 Cytokines
K1 Insulin resistance
K1 Ácidos grasos monoinsaturados
K1 Ácido oléico
K1 PPAR alfa
K1 Receptores de cannabinoides
K1 Ingestión de energía
K1 Obesidad
K1 Inflamación
K1 Peso corporal
K1 Citocinas
K1 Resistencia a la insulina
AB Obesity is currently a major epidemic in the developed world. However, we lack a wide range of effective pharmacological treatments and therapies against obesity, and those approved are not devoid of adverse effects. Dietary components such as palmitoleic acid have been proposed to improve metabolic disbalance in obesity, although the mechanisms involved are not well understood. Both palmitoleic acid (POA) and oleic acid (OA) can be transformed in N-acylethanolamines (NAEs), mediating the effects of dietary POA and OA. To test this hypothesis, here, we study the effects on food intake and body weight gain of palmitoleylethanolamide (POEA) and the OA-derived NAE analogue, oleoylethanolamide (OEA), in Sprague-Dawley rats with a hypercaloric cafeteria diet (HFD). Plasma biochemical metabolites, inflammatory mediators, and lipogenesis-associated liver protein expression were also measured. The results indicate that POEA is able to improve health status in diet-induced obesity, decreasing weight, liver steatosis, inflammation, and dyslipemia. The action of POEA was found to be almost identical to that of OEA, which is an activator of the nuclear peroxisome proliferator receptor alpha (PPARα), and it is structurally related to POEA. These results suggest that the dietary administration of either POA or POEA might be considered as nutritional intervention as complementary treatment for complicated obesity in humans.
PB MDPI
YR 2021
FD 2021-07-28
LK http://hdl.handle.net/10668/4518
UL http://hdl.handle.net/10668/4518
LA en
NO Tovar R, Gavito AL, Vargas A, Soverchia L, Hernandez-Folgado L, Jagerovic N, et al. Palmitoleoylethanolamide Is an Efficient Anti-Obesity Endogenous Compound: Comparison with Oleylethanolamide in Diet-Induced Obesity. Nutrients. 2021 Jul 28;13(8):2589
DS RISalud
RD Apr 6, 2025