TY - JOUR AU - Tisch, Nathalie AU - Freire-Valls, Aida AU - Yerbes, Rosario AU - Paredes, Isidora AU - La Porta, Silvia AU - Wang, Xiaohong AU - Martín-Pérez, Rosa AU - Castro, Laura AU - Wong, Wendy Wei-Lynn AU - Coultas, Leigh AU - Strilic, Boris AU - Gröne, Hermann-Josef AU - Hielscher, Thomas AU - Mogler, Carolin AU - Adams, Ralf H AU - Heiduschka, Peter AU - Claesson-Welsh, Lena AU - Mazzone, Massimiliano AU - López-Rivas, Abelardo AU - Schmidt, Thomas AU - Augustin, Hellmut G AU - Ruiz de Almodovar, Carmen PY - 2019 DO - 10.1172/JCI122767 UR - http://hdl.handle.net/10668/14448 T2 - The Journal of clinical investigation AB - During developmental angiogenesis, blood vessels grow and remodel to ultimately build a hierarchical vascular network. Whether, how, cell death signaling molecules contribute to blood vessel formation is still not well understood. Caspase-8 (Casp-8),... LA - en KW - Angiogenesis KW - Apoptosis pathways KW - Caspases and caspase substrates KW - Retinopathy KW - Animals KW - Animals, Newborn KW - Antigens, CD KW - Cadherins KW - Caspase 8 KW - Cell Death KW - Cell Movement KW - Cell Proliferation KW - Endothelial Cells KW - Female KW - Human Umbilical Vein Endothelial Cells KW - Humans KW - Lung KW - Mice KW - Mice, Knockout KW - Necroptosis KW - Neovascularization, Pathologic KW - Neovascularization, Physiologic KW - Oxygen KW - Phosphorylation KW - Receptor-Interacting Protein Serine-Threonine Kinases KW - Retina KW - Signal Transduction KW - p38 Mitogen-Activated Protein Kinases TI - Caspase-8 modulates physiological and pathological angiogenesis during retina development. TY - research article VL - 129 ER -