RT Journal Article
T1 Pulmonary embolism and 3-month outcomes in 4036 patients with venous thromboembolism and chronic obstructive pulmonary disease: data from the RIETE registry.
A1 Bertoletti, Laurent
A1 Quenet, Sara
A1 Laporte, Silvy
A1 Sahuquillo, Joan Carles
A1 Conget, Francisco
A1 Pedrajas, José María
A1 Martin, Mar
A1 Casado, Ignacio
A1 Riera-Mestre, Antonio
A1 Monreal, Manuel
K1 Chronic obstructive pulmonary diseases
K1 Deep venous thrombosis
K1 Prognosis
K1 Pulmonary embolism
K1 Venous thromboembolism
K1 Estudios de Cohortes
K1 Enfermedad Pulmonar Obstructiva Crónica
K1 Embolia Pulmonar
K1 Medición de Riesgo
K1 Análisis de Supervivencia
K1 Tasa de Supervivencia
AB BACKGROUNDPatients with chronic obstructive pulmonary disease (COPD) have a modified clinical presentation of venous thromboembolism (VTE) but also a worse prognosis than non-COPD patients with VTE. As it may induce therapeutic modifications, we evaluated the influence of the initial VTE presentation on the 3-month outcomes in COPD patients.METHODSCOPD patients included in the on-going world-wide RIETE Registry were studied. The rate of pulmonary embolism (PE), major bleeding and death during the first 3 months in COPD patients were compared according to their initial clinical presentation (acute PE or deep vein thrombosis (DVT)).RESULTSOf the 4036 COPD patients included, 2452 (61%; 95% CI: 59.2-62.3) initially presented with PE. PE as the first VTE recurrence occurred in 116 patients, major bleeding in 101 patients and mortality in 443 patients (Fatal PE: first cause of death). Multivariate analysis confirmed that presenting with PE was associated with higher risk of VTE recurrence as PE (OR, 2.04; 95% CI: 1.11-3.72) and higher risk of fatal PE (OR, 7.77; 95% CI: 2.92-15.7).CONCLUSIONSCOPD patients presenting with PE have an increased risk for PE recurrences and fatal PE compared with those presenting with DVT alone. More efficient therapy is needed in this subtype of patients.
PB BioMed Central
SN 1465-9921
YR 2013
FD 2013-07-18
LK http://hdl.handle.net/10668/1320
UL http://hdl.handle.net/10668/1320
LA en
NO Bertoletti L, Quenet S, Laporte S, Sahuquillo JC, Conget F, Pedrajas JM, et al. Pulmonary embolism and 3-month outcomes in 4036 patients with venous thromboembolism and chronic obstructive pulmonary disease: data from the RIETE registry. Respir. Res. 2013; 14:75
NO Journal Article; Multicenter Study; Research Support, Non-U.S. Gov't;
DS RISalud
RD Apr 5, 2025