RT Journal Article
RT Book, Section
T1 Humanized Mouse Models to Evaluate Cancer Immunotherapeutics
A1 Guil-Luna, Silvia
A1 Sedlik, Christine
A1 Piaggio, Eliane
A1 Jacks, T
A1 Sawyers, CL
K1 Humanized mice
K1 Immuno-oncology
K1 Preclinical research
K1 Immunotherapy
K1  Cancer
K1 Patient-derived xenograft
K1 Lymphoid-system mice
AB Immunotherapy is at the forefront of cancer treatment. The advent of numerous novel approaches to cancer immunotherapy, including immune checkpoint antibodies, adoptive transfer of CAR (chimeric antigen receptor) T cells and TCR (T cell receptor) T cells, NK (natural killer) cells, T cell engagers, oncolytic viruses, and vaccines, is revolutionizing the treatment for different tumor types. Some are already in the clinic, and many others are underway. However, not all patients respond, resistance develops, and as available therapies multiply there is a need to further understand how they work, how to prioritize their clinical evaluation, and how to combine them. For this, animal models have been highly instrumental, and humanized mice models (i.e., immunodeficient mice engrafted with human immune and cancer cells) represent a step forward, although they have several limitations. Here, we review the different humanized models available today, the approaches to overcome their flaws, their use for the evaluation of cancer immunotherapies, and their anticipated evolution as tools to help personalized clinical decision-making.
PB Annual Reviews
SN 2472-3428
YR 2021
FD 2021-01-01
LK http://hdl.handle.net/10668/19041
UL http://hdl.handle.net/10668/19041
LA en
NO Guil-Luna S, Sedlik C, Piaggio E. Humanized Mouse Models to Evaluate Cancer Immunotherapeutics. Annual Review Of Cancer Biology [Internet]. 4 de marzo de 2021;5(1):119-36
NO The TransImm team is supported by the SiRIC-Curie Program (grant INCa-DGOS-12554), the LabEx DCBIOL (ANR-10-IDEX-0001-02 PSL and ANR-11-LABX-0043), and the Center of Clinical Investigation (CIC IGR-Curie 1428). This work was partially supported by funding from “Consejería de Salud de la Junta de Andalusia” through the project PI-0150-2017.
DS RISalud
RD Apr 19, 2025