TY - JOUR AU - Shakur, Haleema AU - Andrews, Peter AU - Asser, Toomas AU - Balica, Laura AU - Boeriu, Cristian AU - Ciro Quintero, Juan Diego AU - Dewan, Yashbir AU - Druwé, Patrick AU - Fletcher, Olivia AU - Frost, Chris AU - Hartzenberg, Bennie AU - Mejia Mantilla, Jorge AU - Murillo-Cabezas, Francisco AU - Pachl, Jan AU - Ravi, Ramalingam R AU - Rätsep, Indrek AU - Sampaio, Cristina AU - Singh, Manmohan AU - Svoboda, Petr AU - Roberts, Ian PY - 2009 DO - 10.1186/1745-6215-10-109 UR - http://hdl.handle.net/10668/1830 T2 - Trials AB - BACKGROUNDCerebral oedema is associated with significant neurological damage in patients with traumatic brain injury. Bradykinin is an inflammatory mediator that may contribute to cerebral oedema by increasing the permeability of the blood-brain... LA - en PB - BioMed Central KW - Traumatismos Encefálicos KW - Escala de Coma de Glasgow KW - Humanos KW - Morbilidad KW - Mediadores de Inflamación KW - Efecto Placebo KW - Quinolinas KW - Factores de Riesgo KW - Medical Subject Headings::Diseases::Nervous System Diseases::Central Nervous System Diseases::Brain Diseases::Brain Injuries KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Trauma Severity Indices::Glasgow Coma Scale KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans KW - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Inflammation Mediators KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Data Collection::Vital Statistics::Morbidity KW - Medical Subject Headings::Health Care::Health Care Quality, Access, and Evaluation::Quality of Health Care::Epidemiologic Factors::Effect Modifier, Epidemiologic::Placebo Effect KW - Medical Subject Headings::Chemicals and Drugs::Heterocyclic Compounds::Heterocyclic Compounds, 2-Ring::Quinolines KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Statistics as Topic::Probability::Risk::Risk Factors KW - Medical Subject Headings::Named Groups::Persons::Age Groups::Adult TI - The BRAIN TRIAL: a randomised, placebo controlled trial of a Bradykinin B2 receptor antagonist (Anatibant) in patients with traumatic brain injury TY - research article ER -