RT Journal Article
T1 SARS-CoV-2 infection: The role of cytokines in COVID-19 disease.
A1 Costela-Ruiz, Víctor J
A1 Illescas-Montes, Rebeca
A1 Puerta-Puerta, Jose M
A1 Ruiz, Concepción
A1 Melguizo-Rodríguez, Lucia
K1 COVID-19
K1 Chemokines
K1 Cytokine storm
K1 Growth factors
K1 SARS-CoV-2
AB COVID-19 disease, caused by infection with SARS-CoV-2, is related to a series of physiopathological mechanisms that mobilize a wide variety of biomolecules, mainly immunological in nature. In the most severe cases, the prognosis can be markedly worsened by the hyperproduction of mainly proinflammatory cytokines, such as IL-1, IL-6, IL-12, IFN-γ, and TNF-α, preferentially targeting lung tissue. This study reviews published data on alterations in the expression of different cytokines in patients with COVID-19 who require admission to an intensive care unit. Data on the implication of cytokines in this disease and their effect on outcomes will support the design of more effective approaches to the management of COVID-19.
YR 2020
FD 2020-06-02
LK http://hdl.handle.net/10668/15704
UL http://hdl.handle.net/10668/15704
LA en
DS RISalud
RD Apr 14, 2025