RT Journal Article T1 Trajectories of alcohol consumption during life and the risk of developing breast cancer. A1 Donat-Vargas, Carolina A1 Guerrero-Zotano, Angel A1 Casas, Ana A1 Baena-Cañada, Jose Manuel A1 Lope, Virginia A1 Antolin, Silvia A1 Garcia-Saenz, Jose Angel A1 Bermejo, Begoña A1 Muñoz, Montserrat A1 Ramos, Manuel A1 de Juan, Ana A1 Jara Sanchez, Carlos A1 Sanchez-Rovira, Pedro A1 Anton, Antonio A1 Brunet, Joan A1 Gavila, Joaquin A1 Salvador, Javier A1 Arriola Arellano, Esperanza A1 Bezares, Susana A1 Fernandez de Larrea-Baz, Nerea A1 Perez-Gomez, Beatriz A1 Martin, Miguel A1 Pollan, Marina K1 Alcohol drinking K1 Breast neoplasms K1 Case-control studies K1 Middle aged AB Whether there are lifetime points of greater sensitivity to the deleterious effects of alcohol intake on the breasts remains inconclusive. To compare the influence of distinctive trajectories of alcohol consumption throughout a woman's life on development of breast cancer (BC). 1278 confirmed invasive BC cases and matched (by age and residence) controls from the Epi-GEICAM study (Spain) were used. The novel group-based trajectory modelling was used to identify different alcohol consumption trajectories throughout women's lifetime. Four alcohol trajectories were identified. The first comprised women (45%) with low alcohol consumption ( The greater the alcohol consumption accumulated throughout life, the greater the risk of BC, especially in postmenopausal women. Alcohol consumption during adolescence may particularly influence BC risk. PB Nature Publishing Group YR 2021 FD 2021-07-08 LK http://hdl.handle.net/10668/18494 UL http://hdl.handle.net/10668/18494 LA en NO Donat-Vargas C, Guerrero-Zotano Á, Casas A, Baena-Cañada JM, Lope V, Antolín S, et al. Trajectories of alcohol consumption during life and the risk of developing breast cancer. Br J Cancer. 2021 Oct;125(8):1168-1176 DS RISalud RD Apr 9, 2025