TY  - JOUR
AU  - Pastor-Villaescusa, Belén
AU  - Caballero-Villarraso, Javier
AU  - Cañete, M Dolores
AU  - Hoyos, Raúl
AU  - Maldonado, José
AU  - Bueno, Gloria
AU  - Leis, Rosaura
AU  - Gil, Ángel
AU  - Cañete, Ramón
AU  - Aguilera, Concepción M
PY  - 2016
DO  - 10.1186/s13063-016-1403-4
UR  - http://hdl.handle.net/10668/2321
T2  - Trials
AB  - BACKGROUNDOverweight and obesity are considered to be serious public health problems. In pediatric populations, insulin resistance, dyslipidemia, and hypertension associated with obesity occur with increased frequencies. Metformin is an oral...
LA  - en
PB  - BioMed Central
KW  - Metformin
KW  - Children
KW  - Obesity
KW  - Puberty
KW  - Lifestyle intervention
KW  - Microbiota
KW  - Polymorphisms
KW  - Niño
KW  - Método doble ciego
KW  - Dislipidemias
KW  - Variación genética
KW  - Hipoglucemiantes
KW  - Inflamación
KW  - Resistencia a la insulina
KW  - Síndrome X metabólico
KW  - Metformina
KW  - Obesidad
KW  - Farmacogenética
KW  - Estudios prospectivos
KW  - Pubertad
KW  - Salud pública
KW  - Distribución aleatoria
KW  - Indice de masa corporal
KW  - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Mass Index
KW  - Medical Subject Headings::Diseases::Cardiovascular Diseases
KW  - Medical Subject Headings::Named Groups::Persons::Age Groups::Child
KW  - Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Diabetes Mellitus
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Double-Blind Method
KW  - Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Lipid Metabolism Disorders::Dyslipidemias
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation
KW  - Medical Subject Headings::Diseases::Cardiovascular Diseases::Vascular Diseases::Hypertension
KW  - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Physiological Effects of Drugs::Hypoglycemic Agents
KW  - Medical Subject Headings::Diseases::Pathological Conditions, Signs and Symptoms::Pathologic Processes::Inflammation
KW  - Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Glucose Metabolism Disorders::Hyperinsulinism::Insulin Resistance
KW  - Medical Subject Headings::Diseases::Nutritional and Metabolic Diseases::Metabolic Diseases::Metabolic Syndrome X
KW  - Medical Subject Headings::Chemicals and Drugs::Organic Chemicals::Amidines::Guanidines::Biguanides::Metformin
KW  - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Overweight::Obesity
KW  - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Body Constitution::Body Weights and Measures::Body Size::Body Weight::Overweight
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Study Characteristics as Topic::Epidemiologic Studies::Cohort Studies::Longitudinal...
KW  - Medical Subject Headings::Phenomena and Processes::Reproductive and Urinary Physiological Phenomena::Reproductive Physiological Phenomena::Puberty
KW  - Medical Subject Headings::Health Care::Environment and Public Health::Public Health
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Epidemiologic Methods::Epidemiologic Research Design::Random Allocation
KW  - Medical Subject Headings::Phenomena and Processes::Microbiological Phenomena::Microbiota::Gastrointestinal Microbiome
KW  - Medical Subject Headings::Disciplines and Occupations::Health Occupations::Pharmacology::Pharmacogenetics
TI  - Evaluation of differential effects of metformin treatment in obese children according to pubertal stage and genetic variations: study protocol for a randomized controlled trial.
TY  - research article
ER  -