%0 Journal Article
%A Dierssen-Sotos, Trinidad
%A Palazuelos-Calderon, Camilo
%A Jimenez-Moleon, Jose-Juan
%A Aragones, Nuria
%A Altzibar, Jone M
%A Castaño-Vinyals, Gemma
%A Martin-Sanchez, Vicente
%A Gomez-Acebo, Ines
%A Guevara, Marcela
%A Tardon, Adonina
%A Perez-Gomez, Beatriz
%A Amiano, Pilar
%A Moreno, Victor
%A Molina, Antonio J
%A Alonso-Molero, Jessica
%A Moreno-Iribas, Conchi
%A Kogevinas, Manolis
%A Pollan, Marina
%A Llorca, Javier
%T Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project.
%D 2018
%U http://hdl.handle.net/10668/12233
%X Reproductive factors are well known risk factors for breast cancer; however, little is known about how genetic variants in hormonal pathways interact with that relationship. One thousand one hundred thirty nine cases of breast cancer in women and 1322 frequency-matched controls were compared. Genetic variants in hormonal pathways (identified in the Kyoto Encyclopedia of Genes and Genomes) were screened according to their relationship with breast cancer using the Cochran-Armitage statistic. Information on reproductive factors was obtained using a face-to-face questionnaire. The interaction among the selected genetic variants and reproductive factors was tested with logistic regression. Concerning C allele in rs2229712, compared to nulliparity in non-carriers the ORs for 1-2 and > 2 deliveries were 0.48 (0.28-0.81) and 0.34 (0.19-0.59), and in C carriers they were 0.92 (0.42-1.98) and 0.71 (0.31-1.61). Similar results were found in women carrying the C allele in rs1269851. Carriers of Allele T in rs35652107 and allele C in rs6018027 had the delivery number effect more pronounced. The number of deliveries had a dose-response protective effect on breast cancer; women carrying C allele in rs2229712 did not benefit from this protective effect.
%K Breast cancer
%K Genetic interactions
%K Reproductive factors
%~