RT Journal Article
T1 Can clinicopathological factors improve the prediction of metastasis to nonsentinel lymph nodes in patients with breast cancer?
T2 ¿Pueden los factores clínicopatológicos mejorar la predicción de metástasis en ganglios linfáticos no centinelas en pacientes con cáncer de mama?
A1 García-Mejido, José A
A1 Sánchez-Sevilla, Miguel
A1 González-Martínez, Jesús
A1 Fernández-Palacín, Ana
A1 Sainz-Bueno, José A
K1 Amplificación de ácido nucleico/OSNA
K1 CK19
K1 Carcinoma breast cancer
K1 Carcinoma cáncer de mama
K1 Carga tumoral
K1 Ganglio centinela/SLN
K1 Nucleic acid amplification/OSNA
K1 Sentinel lymph node/SLN
K1 Tumor load CK19
AB To determine whether clinicopathological characteristics can improve the prediction of metastasis to nonsentinel lymph nodes (NSLNs) over the use of only mRNA copy number in sentinel lymph node (SLN) biopsies. This was a retrospective, observational study that included a total of 824 patients with T1-3 breast cancer who had clinically negative, ultrasound-negative axilla without evidence of metastasis and who underwent one-step nucleic acid amplification in SLN biopsies. 118 required a complete axillary lymph node dissection (ALNhD). About 35.6% (42/118) had metastases to a NSLN, and 64.4% (76/118) had no metastasis to a NSLN. The ROC curve of the total tumor load (TTL) presented an area under the curve (AUC) of 0.651 (95%; CI: 0.552-0.751). The 7294 copies of CK19 mRNA were established as the optimal cutoff point, with sensitivity: 93%, specificity: 63%, positive predictive value: 44%, and negative predictive value: 91%. By associating the clinicopathological parameters (multicentricity, pooled immunohistochemistry [IHC], and progesterone receptors), the AUC went up to 0.752 (95% CI: 0.663-0.841). Clinicopathological factors should be considered together with the total CK19 mRNA copy number (the TTL) of the SLNs to improve the predictive capacity of metastatic involvement of the NSLNs.
YR 2022
FD 2022
LK http://hdl.handle.net/10668/21791
UL http://hdl.handle.net/10668/21791
LA en
DS RISalud
RD Apr 11, 2025